Cell Signaling of Host Defense

由迈克尔·B·费斯勒医学博士领导的国家环境卫生科学研究所内壁研究部呼吸生物学实验室的宿主防御小组现在进入NIEHS的第13个年头。自上次年度报告以来出版的出版物包括： 1.一份由cd4(一种T细胞基因)驱动的癌症基因k-ras的表达导致非典型增殖性肺炎的合作报告。 2.关于药物辛伐他汀对与免疫受体TLR2结合的蛋白质的影响的合作报告。 3.一份关于胆固醇转运蛋白abcg1抑制类似结节病的肺部变化的合作报告。 4.关于流感肺炎研究模型的书的章节 5.一篇资深作者的论文，确定Lrch4蛋白是一种控制炎症的新受体。 6.针对慢性阻塞性肺疾病中性粒细胞的药物的社论 7.一份资深作者出版物，表明IRGM基因变异与克罗恩病的风险有关 8.一位资深作者报告指出，脂类胆汁酸是急性呼吸窘迫综合征的生物标记物。 自我们上次报告以来的其他成就包括：费斯勒博士就一种潜在的干预肺部炎症的新策略提交了专利申请(第62/664,805号(4/30/18))，费斯勒博士获得了《美国呼吸细胞和分子生物学杂志》的最佳评审员奖，该杂志任命费斯勒博士为副主编，任命费斯勒博士为路易斯安那州立大学科布雷项目外部咨询委员会的成员，并在几次国内/国际会议上以口头陈述和海报的形式展示了费斯勒博士团队的研究结果。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 13th year at the NIEHS. Publications since the last annual report include: 1. a collaborative report that CD4 (a T cell gene)-driven expression of the cancer gene K-ras causes an atypical proliferative pneumonitis 2. a collaborative report of the effects of the drug simvastatin on the proteins that bind to the immune receptor TLR2. 3. a collaborative report that the cholesterol transporter ABCG1 suppresses changes in the lung that mimic the disease sarcoidosis 4. a book chapter about research modeling of influenza pneumonia 5. a senior-author paper identifying the protein Lrch4 as a novel receptor that controls inflammation. 6. an editorial on drugs that target the neutrophil in COPD 7. a senior author publication showing that variants of the gene IRGM associate with risk for Crohn's disease 8. a senior author report identifying the lipid cholestenoic acid as a biomarker in acute respiratory distress syndrome. Additional accomplishments since our last report include filing of a patent application by Dr. Fessler on a potential novel strategy for intervening on lung inflammation (No. 62/664,805 (4/30/18)), receipt by Dr. Fessler of a 'Top Reviewer Award' by American Journal of Respiratory Cell and Molecular Biology, appointment of Dr. Fessler as an Associate Editor by the same journal, appointment of Dr. Fessler as a member of the External Advisory Committee of the LSU COBRE program, and presentation of findings from Dr. Fessler's group, in the form of oral presentations and posters, at several national/international meetings.