Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

摘要 在第二阶段SBIR中，Koronis Biomedical Technologies建议开发和评估一种完全可植入的 在啮齿动物研究中监测左心室压力和容积（P-V）的无线设备。转基因模型 通过对啮齿动物的假设驱动的研究， 在学术研究中的机制途径，并支持新化合物的开发， 大型制药公司的药品。因此，越来越重要的是， 准确和全面地评估小鼠和大鼠模型的心脏功能。虽然植入了遥测 压力系统已经成功地商业化用于小鼠和大鼠，该装置还测量 到目前为止，在自由漫游的啮齿动物中还没有实时体积。所提出的微型、轻量、完全 植入式器械将使用导纳测量技术收集压力和体积测量值 并将测量的数据无线发送到附近的基站。

Abstract In this Phase II SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the development of novel compounds and medications by large pharmaceutical companies. As a result, it has become increasingly important to accurately and thoroughly evaluate cardiac function in the mouse and rat model. Although implanted telemetric pressure systems have been successfully commercialized for both mice and rats, a device that also measures real-time volume in a free-roaming rodent has been absent to date. The proposed miniature, lightweight, fully implanted device will collect pressure and volume measurements using an admittance measurement technique and wirelessly transmit the measured data to a nearby base station.