Center of Biomedical Research Excellence in Pathogen Host Interactions

抽象管理核心(核心A) 核心A的作用是通过实现以下目标来实现总体部分确定的目标(具体目标) 具体目标如下：1)改进第一阶段开发的行政核心，增加新的 在第一阶段取得成功的科学人员2)监测研究人员的里程碑并分享 向调查人员和领导班子提供信息。3)协调辅导活动和互动 与内部和外部导师以及外部咨询委员会合作。这包括立即规划 为每个调查员提供一份R01申请。4)建立和维护第一阶段和 第二阶段调查人员将加强已有的合作并促进独立 研究小组。5)管理可持续的技术核心，以支持生物医学的持续增长 在密歇根州立大学研究企业，并向P.I.和领导团队报告 核心。6)与赞助项目办公室(OSP)合作管理COBRE的财务方面，并 参与Cobre的学院和院系的财务官员，并维护Cobre网站和 协调外展活动。提出了具体的计划，以实现上述每一个目标。在……里面 此外，调查员服务和外联活动将集中在核心A。调查员服务包括 由我们最成功的第一阶段研究人员在准备拨款申请方面提供个人协助。另外， 将提供科学插图服务，以编制有效的教科书质量的插图 手稿和拨款申请。同一人也是一名专业的网页设计师，并将负责 我们的Cobre网站，这将是我们外联工作的主要组成部分。另一项调查员服务 将是每个项目的月度财务预测。在第一阶段的第四年，科布雷结束了赠款 去年，只剩下1.69%的原始资金。这是可能的，因为调查人员收到了 定期反馈和提醒他们在赠款年度期间的支出速度。这将是 继续第二阶段。指导是管理核心和Cobre业务经理的关键角色 将监测里程碑和出席Cobre定期会议(每月研讨会、每月工作- 进度会议，每月与外部和内部导师联系，每年参加Cobre 由外部咨询委员会和所有导师参加的研讨会)。这是一个里程碑，在 第二阶段资助机会公告将在年底前提交一份重大研究项目补助金(RPG) 资金的第二年。这将受到仔细的监控，私家侦探、导师和领导团队 一旦拨款到位，科布雷将开始与每一名研究人员合作，以开发具有竞争力的 R01应用程序，具有充足的初步数据。包括了解决未能达到里程碑的问题的机制， 但在担任公安部部长的S中，他发现，设定很高的期望，保持一种 积极的态度可以有效地说服侦查人员提高自己的期望和表现。

Abstract Administrative Core (Core A) The role of Core A is to implement the goals (Specific Aims) identified in the Overall Section by achieving the following Specific Aims: 1) Improve the Administrative Core developed in Phase I by addition of new scientific personnel who were successful in Phase I. 2) Monitor investigator milestones and share this information with the investigators and the leadership team. 3) Coordinate mentoring activities and interactions with internal and external mentors and the External Advisory Committee. This includes immediate planning for an R01 application for each Investigator. 4) Establish and maintain communication between Phase I and Phase II investigators to enhance collaborations that already exist and promote development of independent research groups. 5) Manage sustainable Technical Cores to support continued growth of the biomedical research enterprise at MSU, and report to the P.I. and leadership team on the usage and effectiveness of the Cores. 6) Manage fiscal aspects of the COBRE in partnership with the Office of Sponsored Projects (OSP) and fiscal officers in the colleges and departments involved in the COBRE and maintain the COBRE web site and coordinate outreach activities. Specific plans are presented to allow each of these aims to be achieved. In addition, investigator services and outreach activities will be centered in Core A. Investigator services include individual assistance in preparing grant applications by our most successful Phase 1 investigator. Also, the services of a scientific illustrator will be available for preparing effective, textbook quality illustrations for manuscripts and grant applications. The same individual is also an expert web designer, and will be in charge of our COBRE Web Site, which will be a major component of our outreach efforts. Another investigator service will be monthly financial projections for each project. During Year 4 of Phase I, the COBRE ended the grant year with only 1.69% of the original funds remaining. This was possible only because investigators received regular feedback and reminders regarding their rate of spending during the course of the grant year. This will continue in Phase II. Mentoring is a key role for the Administrative Core, and the COBRE Business manager will monitor milestones and attendance at regular COBRE meetings (a monthly seminar, a monthly work-in- progress meeting, monthly contact with external and internal mentors and yearly participation in a COBRE Symposium attended by the External Advisory Committee and all mentors). A milestone that is stated in the Phase II Funding Opportunity Announcement is submitting a major Research Project Grant (RPG) by the end of the second year of funding. This will be monitored carefully, and the P.I., mentors, and the leadership team of the COBRE will begin working with each investigator as soon as the grant is funded to develop a competitive R01 application with ample preliminary data. Mechanisms to address failure to meet milestones are included, but in the P.I.’s role as department head, he has found that setting high expectations and maintaining a positive attitude can effectively persuade investigators to raise their own expectations and performance.