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Identification of small molecule inhibitors of miR-155 expression in Th17 cells

Identification of small molecule inhibitors of miR-155 expression in Th17 cells
Th17细胞中miR-155表达的小分子抑制剂的鉴定
批准号：
10005785
负责人：
Marc Ferrer-Alegre
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10005785
关键词：
Autoimmune DiseasesBiological AssayBiologyCellsChemicalsCollaborationsCrohn&aposs diseaseDiseaseExperimental Autoimmune EncephalomyelitisExtramural ActivitiesGenomicsGoalsInformaticsModelingMultiple SclerosisPharmaceutical ChemistryPhenotypeProcessProductionPsoriasisResearchResearch PersonnelSynthesis ChemistryTestingUnited States National Institutes of HealthValidationWorkassay developmentbasedrug developmentdrug discoveryinhibitor/antagonistlead optimizationmouse modelnew technologynovelscreeningsmall moleculesmall molecule inhibitorsmall molecule therapeuticstherapeutic developmenttool

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中文摘要
翻译
在此期间，项目组致力于验证和表征在之前完成的初级miR-155筛查中确定的命中化合物。在使用原代细胞的功能分析中，化合物被证实有能力下调IL-17的产生。选定的HIT分子已经在多发性硬化症的小鼠模型EAE中进行了测试。经过进一步的表征和验证，具有良好活性的分子可能有望用于多发性硬化症、克罗恩病和牛皮癣等自身免疫性疾病的治疗。
英文摘要
During this period, the project team worked to validate and characterize hit compounds identified in the previously completed primary miR-155 screen. Compounds were confirmed for their ability to down-regulate Il-17 production in functional assays using primary cells. Select hit molecules have been advanced toward testing in EAE, a mouse model for multiple sclerosis. Following additional characterization and validation, molecules with promising activity profiles may hold promise for the treatment of autoimmune diseases like multiple sclerosis, Crohn's disease and psoriasis.
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