Cancer Epidemiology and Prevention Program

摘要：癌症流行病学与预防(CEP) 癌症流行病学和预防(CEP)计划的首要目标是减轻癌症负担 和死亡率在我们的集水区和更远的地方通过三个互动主题从 从癌症倡议到癌症预防和早期发现。主题1是发现风险和因果关系 癌症发生和进展的因素，有特定的目的来发现和表征新的 癌症发展的可改变和不可改变的风险和原因因素。主题2：预防癌症 具体目的是发现和评估新的抗癌天然化合物和疫苗，以减少 癌症发病率。主题3是癌症筛查和早期发现，其具体目标是开发和 验证用于癌症早期诊断的新生物标志物和现代成像技术，以改善 癌症转归和癌症死亡的减少。这些主题反映了主要的工作组和倡议 该组织通过项目间合作，将项目成员与其他癌症中心研究人员联合起来 为实现这些具体目标而进行的合作。 在医学博士James Herman(联席领导)和医学博士袁建民(联席领导)的领导下，CEP 有26名成员，代表匹兹堡大学两个学院的11个系。这些计划 成员已获得540万美元(年度总额直接)研究资助，其中360万美元来自 NCI和其他来源的180万美元。所有CEP成员都从事与癌症相关的研究，重点是 癌症发生、原发癌疗效的新危险/致病因素的发现 癌症筛查和早期发现方法的预防策略和有效性。CEP成员 与BCC计划合作并赞扬其努力，该计划的重点是实施风险 行为改变计划，如戒烟、体重控制和减肥。2015年至 2019年8月，CEP成员发表了639篇与癌症相关的论文，这些论文源于10%的计划内， 27%为方案间协作，81%为机构间协作，包括#年影响较大的出版物 《科学》、《自然》、《美国医学会》、《柳叶刀》、JNCI和JCO。项目成员带来了他们的科学活力和 向UPMC Hillman癌症中心(HCC)提供基于人群的研究专业知识，并提供独特的教育 和培训经验给下一代科学家，以进行尖端的翻译研究 癌症病因学和预防。在HCC的杰出支持下，这一高效的CEP 成功地在计划成员之间创建了与CC其他计划成员以及 其他癌症中心，这导致了许多促进该项目研究的团队科学项目 议程。在肝细胞癌战略计划的指导下，CEP成员将制定和建立大型倡议和 实施对肝癌集水区癌症负担有重大影响的研究项目。

Abstract: Cancer Epidemiology and Prevention (CEP) The overarching goal of the Cancer Epidemiology and Prevention (CEP) Program is to reduce cancer burden and mortality in our catchment area and beyond through three interactive themes on the continuum from cancer initiations to cancer prevention and early detection. Theme 1 is Discovery of Risk and Causative Factors for Cancer Development and Progression with a specific aim to discover and characterize novel modifiable and unmodifiable risk and causal factors for cancer development. Theme 2 is Cancer Prevention with a specific aim to discover and evaluate novel anti-cancer natural compounds and vaccines for reduction of cancer incidence. Theme 3 is Cancer Screening and Early Detection with a specific aim to develop and validate novel biomarkers and modern imaging technologies for early diagnosis of cancer, for improvement of cancer outcomes and reduction of cancer death. These themes reflect major working groups and initiatives that coalesce program members with other cancer center investigators, through inter-programmatic collaborations to achieve these specific aims. Under the leadership of James Herman, MD (co-leader) and Jian-Min Yuan, MD, PhD (co-leader), the CEP has 26 members representing 11 departments in 2 schools of the University of Pittsburgh. These Program members have been awarded $5.4M (annual total direct) research grant funding, of which $3.6M is from the NCI and $1.8M from other sources. All CEP members are engaged in cancer-relevant research focusing on the discovery of novel risk/causative factors for the development of cancer, the efficacy of primary cancer prevention strategies and effectiveness of cancer screening and early detection methods. CEP members collaborate with and compliment the efforts of the BCC program, which focuses on implementation of risk behavioral change programs such as smoking cessation and weight control and reduction. Between 2015 and August 2019, CEP members published 639 cancer-relevant papers that resulted from 10% intra-programmatic, 27% inter-programmatic, and 81% inter-institutional collaborations and included high-impact publications in Science, Nature, JAMA, Lancet, JNCI, and JCO. The program members bring their scientific vigor and population-based research expertise to UPMC Hillman Cancer Center (HCC) and provide unique education and training experience to the next generation of scientists to conduct cutting-edge translational research on cancer etiology and prevention. With the outstanding support of HCC, this highly effective CEP has successfully created synergy among the Program members with members of HCC other programs as well as other cancer centers, which have resulted in many team science projects that advance the program’s research agenda. Guided by the HCC strategic plan, the CEP members will develop and build large initiatives and implement research projects that have significant impact on cancer burden in the HCC catchment area.