Optimized Medial Olivocochlear Reflex Screening and Testing Module

本研究的目的是开发一个优化的听力测试和筛查模块，并紧凑 便携式设备，可用于有效地评估周围神经功能(包括耳蜗后 使用内侧橄榄耳蜗反射(MOCR)。通过MOCR测量神经功能 通过记录引起神经反射的条件下的耳声发射(OAE)来完成。这 反射已被证明在神经障碍患者中是异常的。这个项目的重点将是 开发一种筛查模块，它结合了OAE筛查和MOCR的测量 同样的测试程序。拟议研究的目标人群是婴儿，特别是 不定期进行ABR筛查的环境。将MOCR添加到以下情况的筛选 不进行ABR将解决OAE筛查的缺点，即错过了神经形式的听力 损失。虽然婴儿筛查是将获得的数据的重点，但优化评估 除了已经可行的对侧条件外，同侧和双耳条件下的MOCR将开放 儿童和成人的其他临床应用。这个团队有与MOCR相关的研究记录， 神经性听力损失，并将MOCR范例整合到临床系统中，为直接 至第二阶段申请。此第二阶段提案将解决测试和测试中的准确性、效率和自动化问题 分析，并将通过智能听力在系统中建立现有的OAE测量和分析能力 系统。目标1将侧重于MOCR收购的实施、优化和噪音消除 系统。AIM 2将专注于开发一种紧凑型便携式无线MOCR OAE筛查设备。 AIM 3将对两种创新的MOCR记录方法进行大量的综合评估 在托儿所和根据新生儿转介的婴儿的随访测试期间 听力筛查结果。这些技术还将与已建立的前向掩蔽MOCR进行比较 成人的记录范例。此外，患有神经障碍(例如，听觉障碍)的婴儿、儿童和成人 神经病)将进行测试。

The objective of this study is to develop an optimized hearing testing and screening module, and compact portable device, that can be used to efficiently assess peripheral neural function (including retrocochlear disorders) using the medial olivocochlear reflex (MOCR). Measuring neural function via the MOCR is accomplished by recording otoacoustic emissions (OAE) under conditions that elicit the neural reflex. This reflex has been shown to be abnormal in patients with neural disorders. The focus of this project will be the development of a screening module that incorporates OAE screening and measurement of the MOCR in the same test procedure. The target population in the proposed research is infants, particularly those in environments where ABR screening is not performed routinely. Addition of the MOCR to screening where ABR is not performed will address the shortcoming of OAE screening which misses neural forms of hearing loss. While infant screening is the focus of the data that will be acquired, optimizing the ability to assess the MOCR in ipsilateral and binaural conditions, in addition to the already feasible contralateral condition, will open additional clinical applications in children and adults. This team has a record of research related to the MOCR, neural hearing loss, and integrating a MOCR paradigm into a clinical system that provides the basis for a direct to Phase II application. This Phase II proposal will address accuracy, efficiency, and automation in testing and analysis, and will build on existing OAE measurement and analysis capability in systems by Intelligent Hearing Systems. Aim 1 will focus on the implementation, optimization and noise cancellation of the MOCR acquisition system. Aim 2 will focus on the development of a compact portable wireless MOCR OAE screening device. Aim 3 will perform a comprehensive evaluation of two innovative MOCR recording methods on a large number of newborns in the nursery and during the time period of follow-up testing of infants referred based on newborn hearing screening results. These techniques will also be compared to an established forward masking MOCR recording paradigm on adults. In addition, infants, children and adults with neural disorders (e.g., auditory neuropathy) will be tested.