Core B: Data and Research Methods

项目摘要 尽管阿片类药物对公共卫生具有重要意义，但针对阿片类药物使用障碍和过量预防的干预措施 经常受到缺乏严格设计和评估的困扰。数据和研究方法(DRM)核心将 支持Cobre项目负责人和试点调查人员克服方法、分析和 传统上阻碍研究项目成功和公共卫生影响的翻译挑战。通过 DRM核心将提供量化的专业知识、研究基础设施和技术资源 加强Cobre项目负责人制作的工作质量，并增强他们的数据 使用/管理容量。DRM核心服务将包括：1)研究设计的方法学咨询 诸如抽样、匹配、调查发展和数据统一等问题；2)统计支助，如 作为统计模型的使用、模型构建程序、模型规范和方法的处理 缺少数据；3)“仪表板”和其他可视化服务，以生成用户友好的交互数据 用于传播和翻译信息的产出；4)提供符合HIPAA标准的数据管理 将提供多层访问、备份和身份验证的系统；5)提供访问和链接 现有和新的全州范围内与过量用药有关的数据库以及记录匹配服务，以丰富 跨项目的成果；以及6)提供培训并促进交流方法， 与过量和阿片类药物相关危害研究有关的计算和分析思想。 DRM核心主任布兰登·马歇尔博士是美国疾病控制与预防中心和美国国立卫生研究院资助的知名研究员，拥有广泛的 在队列研究设计、调查开发和使用先进的定量方法方面的经验， 包括模拟方法，以评估非随机的公共卫生干预措施。他的领导力将是 辅以训练有素的人员，具有流行病学方法、项目管理、数据库方面的专业知识 开发、编程、数据可视化和生物统计学。

Project Summary Despite their public health significance, interventions focusing on opioid use disorder and overdose prevention often suffer from a lack of rigorous design and evaluation. The Data and Research Methods (DRM) Core will support COBRE Project Leaders and pilot investigators in overcoming the methodological, analytical, and translational challenges that have traditionally stymied research project success and public health impact. By providing quantitative expertise, research infrastructure, and technological resources, the DRM Core will strengthen the quality of the work produced by COBRE Project Leaders, and enhance their data use/management capacity. DRM Core services will include: 1) methodological consultation on study design issues such as sampling, matching, survey development, and data harmonization; 2) statistical support, such as the use of statistical models, model-building procedures, model specification, and methods to handle missing data; 3) “dashboarding” and other visualization services to generate user-friendly, interactive data outputs for dissemination and translation of information; 4) providing a HIPAA-compliant data management system which will provide multi-tier access, back-ups, and de-identification; 5) providing access and linkage to existing and new statewide overdose-related databases, as well as record matching services to enrich outcomes across projects; and 6) providing training on and facilitating the exchange of methodological, computational, and analytic ideas related to the study of overdose and opioid-related harms. DRM Core Director Dr. Brandon Marshall is an established CDC- and NIH-funded investigator with extensive experience in cohort study design, survey development, and the use of advanced quantitative methods, including simulation approaches, to evaluate non-randomized public health interventions. His leadership will be supplemented by highly trained staff with expertise in epidemiological methods, project management, database development, programming, data visualization, and biostatistics.