New cardiac ryanodine receptor inhibitors for the treatment of heart failure

我们已经发现，一种被认为在第二阶段解毒中起作用的蛋白质也可以修改构成心脏功能的钙信号。心脏组织中活跃的一小部分蛋白质不同于支持解毒的酶中心，因此可以用作心力衰竭和遗传性心脏疾病的治疗剂。该项目旨在开发该蛋白质的心脏活性部分，以实现最大的疗效并最终用于临床。

We have discovered that a protein that is recognized for its role in phase II detoxification can also modify the calcium signaling that underlies heart function. The small part of the protein that is active in heart tissue differs from the enzyme center that supports detoxification and can thus be used as a therapeutic agent in heart failure and in genetic cardiac conditions. The project is to develop the cardio-active part of the protein for maximum efficacy and for eventual clinical use.