Core B: Human Biology Validation Core

项目摘要/摘要 人类核心-格林伯格U54 CWow 人类生物学验证核心将为CWow提供重要的研究支持。神经退行性变 近年来，疾病病理学和遗传学变得越来越令人兴奋和复杂，主要的 通过这个亚洲发展研究中心完成的工作所产生的进展。在此续订申请中，人类核心将 由Lea T.Grinberg博士和Bruce L.Miller博士领导。安妮·费根博士将领导一个脑脊液阵列分核心 人类的核心目标是：(1)直接支持本CWW的项目(P)，具有良好的特色和 仔细处理来自脊椎病患者和对照的人体组织、生物液和细胞；(2)验证 人类样本中P1-3的相关性结果；(3)开发增强的工具，以提高 为每个生物样品检索的信息。这些核心职能将支持 项目1(PI：GaN)和项目3(PI：Cuervo)，通过提供具有良好特征的人脑和生物液标本 从牛顿疗法中脱身。此外，人类核心将帮助验证CWOW项目的结果，以 加快从板凳到临床的转化。

Project summary/abstract Human Core – Grinberg U54 CWOW The Human Biology Validation core will provide vital research support to the CWOW. Neurodegenerative disease pathology and genetics have become increasingly exciting and complex in recent years, with major advances arising from work accomplished through this ADRC. In this renewal application, the Human Core will be led by Dr. Lea T. Grinberg and Dr. Bruce L. Miller. Dr. Anne Fagan will lead a CSF array sub-core The Human Core goals are to: (1) directly supporting this CWOW’s Projects (P) with well-characterized and carefully treated human tissue, bio-fluids, and cells from tauopathy patients and controls; (2) validating the relevance results from P 1-3 in human specimens; (3) developing enhanced tools for boosting the amount of information retrieved for each single biospecimen samples. These core functions will support the aims of Projects 1 (PI: Gan) and 3 (PI: Cuervo) by providing well-characterized human brain and bio fluid specimens from tauopathies. Moreover, the Human Core will help to validate the findings from the CWOW’s projects to accelerate translation from bench to clinical use.