Profiling Assay for Electrophilicity

在此期间，项目团队致力于优化一种高通量可适应的分析方法，以筛选这种亲电性分析。

During this period, the project team worked to optimize a high-throughput amenable assay to enable screening for this electrophilicity profiling effort. As a center, the NCGC has fostered and maintained over 130 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, the NCGC has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.