Colorado Nutrition Obesity Research Center

项目概要-总体组成部分 这是科罗拉多营养肥胖研究中心的5年竞争性续约申请 （NORC）.科罗拉多NORC的使命是促进营养和肥胖科学的发展， 跨学科，合作，转化研究，并通过促进下一代的发展， 落基山脉地区的科学家。我们现在是在我们的第二十五年的运作，和科罗拉多 NORC现在支持118名普通会员，22名附属会员学员和38名其他附属会员教师 科学家和教育家。我们的普通会员每年产生超过5100万美元的直接成本， 营养/肥胖研究。我们已获得额外2 000万美元的机构资源，以支持 NORC未来5年的研究和教育目标。这项投资建立在4000万美元的基础上。 在过去的10年里，科罗拉多大学及其慈善捐助者投资建设和 经营安舒茨健康与保健中心，并在营养科学方面有计划地建立， 肥胖和健康我们的研究基地从事基础，临床前，临床和社区研究项目， 具有跨学科合作的思维。科罗拉多NORC的中心主题是 预防和治疗肥胖及其代谢并发症，通过更好的营养， 生活方式的改变和药物治疗我们专门建立和促进跨学科的研究， 营养和肥胖在五个方面：1）早期生活的影响; 2）妇女的健康和性别差异; 3）运动 和代谢; 4）代谢调节;和5）营养和体重管理干预，以更好地 健康科罗拉多NORC拥有Paul MacLean博士（主任）和丹尼尔贝塞森博士的强有力领导 （副主任），他将协调一个有影响力的浓缩方案的活动，一个成功的试点 三个高效率的研究核心。他们与校园建立了牢固的合作伙伴关系 领导者，桥梁学科的合作研究。他们引导核心和程序适应 NORC研究基地不断变化的需求。最后，他们招募了一个优秀的团队， 核心/项目领导人和内部/外部顾问，将确保科罗拉多NORC完成其 使命。经过25年的运行，科罗拉多号从未像现在这样处于有利地位，以推进科学的发展。 营养和肥胖在这么多方面，并培养这些领域的下一代领导人。

PROJECT SUMMARY - OVERALL COMPONENT This is an application for a 5 year competitive renewal for the Colorado Nutrition Obesity Research Center (NORC). The MISSION of the Colorado NORC is to advance the science of nutrition and obesity by facilitating interdisciplinary, collaborative, translational research and by fostering the development of the next generation of scientists in the Rocky Mountain region. We are now in our twenty-fifth year of operation, and the Colorado NORC now supports 118 Regular Members, 22 Affiliate Member trainees, and 38 other Affiliate Member faculty scientists and educators. Our regular members generate over $51 million annually in direct costs for nutrition/obesity research. We have secured an additional $20 million in institutional resources to support the NORC's research and educational objectives over the next 5 years. This investment builds upon a $40 million investment from the University of Colorado and its philanthropic donors over the past 10 years to construct and operate the Anschutz Health and Wellness Center and build programmatically in the science of nutrition, obesity, and wellness. Our research base pursues basic, preclinical, clinical, and community research projects, with a mindset for interdisciplinary collaboration. The CENTRAL THEME of the Colorado NORC is the prevention and treatment of obesity and its metabolic complications across the lifespan, through better nutrition, lifestyle modifications, and medical treatments. We specifically build and foster interdisciplinary research on nutrition and obesity in five areas: 1) Early Life Influences; 2) Women's Health and Sex Differences; 3) Exercise and Metabolism; 4) Regulation of Metabolism; and 5) Nutrition and Weight Management Interventions for Better Health. The Colorado NORC has strong leadership with Dr. Paul MacLean (Director) and Dr. Daniel Bessesen (Associate Director), who will coordinate the activities of an impactful enrichment program, a successful pilot program, and three highly productive research cores. They have established strong partnerships with campus leaders that bridge disciplines for collaborative research. They have guided the cores and programs to adapt to the changing needs of the NORC's research base. Finally, they have recruited an outstanding team of core/program leaders and internal/external advisors that will ensure the Colorado NORC accomplishes its mission. After 25 years of operation, the Colorado has never been as well-positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in these fields.