Multiple spatial representations during visually-guided behavior

项目摘要 视觉对于有效控制行动至关重要。背侧流投射到后顶叶皮质(PPC)， 并将视觉输入转换为相应的响应，以指导不同效应器的运动。一个 影响模型提出，背侧流被组织成专门的视觉运动通道，这些通道是 特定于效应器并独立运行。这一提议的实验试图严格测试这一模型 而不是通道引导多个效应器的移动并可以交互的备选方案。我们将首先测试 协调视觉引导行为是否通过记录脑区神经元来招募效应器特有的过程 在协调行为过程中，顶叶触达系统(目标1)和顶叶眼跳系统(目标2)。我们会 然后通过测量强度和功能来测试通道是独立运行还是相互作用 顶视和眼跳系统之间跨区域连贯性的意义(目标3)。尽管 协调对视觉行为的中心作用，伸展的视觉空间和眼球运动如何影响 彼此之间以及购买力平价内部的跨地区互动是否构成这种影响的基础尚不清楚。 了解协调视觉行为的机制将有助于我们理解视觉行为是如何 产生于更一般的不同视觉表示之间的交互。PPC的损坏会导致 视性共济失调，失用和忽视，正在使人虚弱，每年在美国有许多患者患有 巨大的社会成本。了解大脑是如何构建视觉空间表征的 后顶损伤患者的有效治疗。

Project Abstract Vision is critical for effective control of action. The dorsal stream projects to the posterior parietal cortex (PPC), and transforms visual input into corresponding responses to guide movements of different effectors. An influential model proposes that the dorsal stream is organized into dedicated visuomotor channels that are effector-specific and operate independently. Experiments for this proposal seek to rigorously test this model against alternatives in which channels guide movements of multiple effectors and can interact. We will first test whether coordinating visually-guided behaviors recruits effector-specific processes by recording neurons in the parietal reach system (Aim 1) and the parietal saccade system (Aim 2) during coordinated behavior. We will then test whether channels operate independently or interact by measuring the strength and functional significance of cross-areal coherence between the parietal reach and saccade systems (Aim 3). Despite the central role of coordination to visual behavior, how visual space for reaching and eye movements influence each other and whether cross-areal interactions within PPC underlie this influence is not known. Understanding the mechanisms of coordinated visual behavior will help us understand how visual behavior arises from interactions between different visual representations more generally. Damage to the PPC leads to optic ataxia, apraxia and neglect, is debilitating, and is suffered by many patients each year in the US with significant social costs. Understanding how the brain constructs visual-spatial representations underlies the effective treatment of patients with posterior parietal damage.