MGH Next Generation Physician-Scientist Through Stimulating Access to Research in Residency Program (MGH-Next Gen StARR)

项目摘要 医生科学家发挥了独特的作用，在弥合基础科学和临床医生之间的差距，通过 识别重要的临床问题并翻译结果以改善患者护理。可惜 医生科学家的劳动力继续减少，并导致负面的，长期的后果， 生物医学研究许多住院医师项目非常注重获得医学知识，而不是 培养求知欲和生物医学研究领域的介绍。在本建议中，我们的目标是 在住院医师培训期间，提高作为一名医生-科学家的职业生涯的吸引力和准备。 进一步减少兴趣的职业生涯作为一个医生，科学家是有能力确定一个令人鼓舞的 成功的导师有一个关键需要重新强调既定的医生，科学家， 给学员树立榜样心脏生物学、肺部炎症和再生医学是基础 科学领域，极大地受益于强大的医生科学家的劳动力。我们假设早期和 纵向指导与发展研究和专业发展技能相结合的领域 再生医学，心脏和肺生物学将使医生科学家的职业道路有吸引力 和可持续性。为此，我们建议实施马萨诸塞州总医院下一步- 通过刺激获得住院研究（MGH下一代）的一代物理学家-科学家 StARR）计划。该计划将在整个生物医学研究连续体中培养新的医生-科学家 世卫组织将推动心，肺，血液疾病的新预防和治疗措施。的 MGH Next-Gen StARR计划围绕以下三个目标展开：[1] 通过强有力的纵向指导做出重要的科学贡献，重点是领导力 基本要素; [2]发展足够的基本实验室和必要的转化方法，以进行高- 再生医学、心脏代谢和肺生物学领域的高质量研究;以及[3] 制定基于假设的研究问题，开发和执行研究项目，以及 有效地传达他们的科学意义。MGH下一代StARR计划将允许两名居民 在MGH或Broad Institute进行为期12-24个月的研究。的 该计划将由执行指导委员会和外部咨询委员会Jatin M Vyas（医学）领导， 沿着的还有58位多学科和资金充足的研究导师。这些举措旨在 吸引，培训和保留医学博士在血管生物学和再生领域的生物医学研究 在他们职业生涯中最关键的时刻-住院医师培训。

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Unfortunately, the physician-scientist workforce continues to diminish and contributes to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician-scientists as role models to trainees. Cardiac biology, pulmonary inflammation and regenerative medicine are fundamental areas of science that greatly benefits from a robust physician-scientist workforce. We hypothesize that early and longitudinal mentorship combined with development of research and professional development skills in the areas of regenerative medicine, cardiac and pulmonary biology will make the physician-scientist career path attractive and sustainable. To this end, we propose the implementation of the Massachusetts General Hospital Next- Generation Physician-Scientist Through Stimulating Access to Research in Residency (MGH Next-Gen StARR) program. The program will train new physician-scientists throughout the biomedical research continuum who will promote new preventative and therapeutic measures for diseases of the heart, lungs, and blood. The MGH Next-Gen StARR program is centered around the following three objectives: [1] To foster the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials; [2] To develop sufficient basic laboratory and translational approaches necessary to conduct high- quality research in the areas of regenerative medicine, cardiometabolic and pulmonary biology; and [3] To formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science. MGH Next-Gen StARR program will allow two residents from the Department of Medicine to conduct research for 12-24 months at MGH or the Broad Institute. The program will be led by Jatin M Vyas (Medicine), an Executive Steering Committee and External Advisory Board, along with 58 multidisciplinary and well-funded research preceptors. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation in the areas of vascular biology and regenerative medicine at the most critical juncture of their career - residency training.