MoTrPAC Consortium Coordinating Center

总结 缺乏身体活动是一个重大的公共卫生挑战，它是所有年龄段的一系列健康问题的基础。 虽然身体活动（PA）已显示出产生相关的健康益处，但潜在的分子 机制知之甚少。临床和动物研究的协调努力得到以下方面的支持： 生物信息学和化学分析将实现物理活动联盟的分子传感器 （MoTrPAC）的目标是评估PA反应中发生的分子变化。该财团 MoTrPAC协调中心（CCC）将为组织，管理，规划， 与交通和公共行政部有关的标准化、文件编制、监测和报告活动。CCC将发挥 通过加强所有部门的沟通和整合，在确保交通部的凝聚力方面发挥关键作用 研究组成部分，包括临床研究中心、临床前动物研究中心、生物信息学中心， 化学分析网站和各种研究委员会。CCC将制定战略和 通过将MoTrPAC调查人员的活动与数据提供的输入相结合，规划流程 安全监测委员会、外部科学顾问、外部专家和NIH。CCC将促进 与联合体以外的初级和高级研究人员进行互动和沟通， 利用MoTrPAC资源实现总体研究目标。为了实现这些目标， 最大限度地提高MoTrPAC的进度和生产力，CCC将促进团队科学，团队领导， 和创新的领导方法在所有的研究组成部分。战略规划遵循 战略的动态理论的原则将被培养，以评估替代方法，维护 前沿的科学焦点，利用最先进的协调技术，预测挑战， 最大限度地利用未来的机会，以确保联合体的成功。CCC将包括四个集成 由四名高素质的PI领导的组件，他们拥有成功工作的长期记录， 协同作用。CCC的四个组成部分包括行政协调中心（PI Dr. Pahor）、数据中心（Data Center）和数据中心（Data Center）。 管理、分析和质量控制中心（PI Dr.米勒），生物标本储存库（PI Dr. Tracy）， 运动干预核心（PI Rejeski博士）。CCC将采用创新的项目管理工具 和基于网络的运动坚持和饮食跟踪，并将利用出色的跟踪记录， 调查人员在以下方面的专业知识：（a）共同工作;（B）成功协调、管理和领导 涉及PA和其他干预措施的大型长期多中心临床试验;（c）实施严格和 研究的透明度;（d）获取、管理、储存和分析生物样品;（e）开展 动物运动研究;（f）共享资源;（g）公布结果;（h）领导多学科团队。 气候变化协调委员会将确保和促进交通和公共行政部在增进对 分子变化，发生在响应PA，并将这些变化与PA的健康益处。

Summary Physical inactivity is a major public health challenge underlying a broad range of health problems at all ages. While physical activity (PA) has shown to produce relevant health benefits, the underlying molecular mechanisms are poorly known. The coordinated effort of clinical and animal studies supported by bioinformatics and chemical analyses will achieve the Molecular Transducers of Physical Activity Consortium (MoTrPAC) goals of assessing the molecular changes that occur in response to PA. The Consortium Coordinating Center (CCC) for the MoTrPAC will provide support for the organization, administration, planning, standardization, documentation, monitoring and reporting activities relating to the MoTrPAC. The CCC will play a pivotal role in ensuring the cohesion of the MoTrPAC by enhancing communication and integration across all study components, including the Clinical Sites, the Preclinical Animal Study Sites, the Bioinformatics Center, the Chemical Analysis Sites, and the various study committees. The CCC will develop strategies and strategic planning processes by integrating activities of the MoTrPAC investigators with the input provided by the Data Safety Monitoring Board, the External Scientific Advisors, outside experts, and the NIH. The CCC will facilitate interactions and communications with junior and senior investigators outside the consortium to maximize the use of the MoTrPAC resources toward achieving the overall research goals. To accomplish these goals and maximize the progress and productivity of the MoTrPAC, the CCC will promote team science, team leadership, and innovative leadership approaches across all study components. Strategic planning that follows the principles of the dynamic theory of strategy will be fostered to evaluate alternative approaches, maintain the cutting-edge scientific focus, leverage state-of-the-art coordination technologies, anticipate challenges, and maximize future opportunities to ensure the success of the consortium. The CCC will comprise four integrated components led by four highly qualified PIs who have a long-lasting track record of successfully working in synergy. The four CCC components comprise the Administrative Coordinating Center (PI Dr. Pahor), the Data Management, Analysis, and Quality Control Center (PI Dr. Miller), the Biospecimens Repository (PI Dr. Tracy), and the Exercise Intervention Core (PI Dr. Rejeski). The CCC will employ innovative project management tools and web-based tracking of exercise adherence and diet, and will capitalize on the outstanding track record and expertise of its investigators in: (a) working together; (b) successfully coordinating, managing, and leading large long-term multicenter clinical trials involving PA and other interventions; (c) implementing rigor and transparency in research, (d) acquiring, managing, storing and analyzing biological samples; (e) conducting animal exercise studies; (f) sharing resources; (g) publishing results; and (h) leading multidisciplinary teams. The CCC will ensure and promote the continued success of the MoTrPAC in advancing knowledge about the molecular changes that occur in response to PA, and relating these changes to the health benefits of PA.