Tinnitus Treatment with Targeted Electric Stimulation

主要研究者/项目负责人（末位、首位、中位）：曾凡刚 摘要 目前的行政补充建议检查耳鸣之间的关系， 认知和治疗阿尔茨海默病和相关痴呆（ADRD）患者的耳鸣。 耳鸣是一种听力障碍，在没有听觉刺激的情况下产生听觉感知， 影响13-52%的ARDR人群。使用与活性母体相同的实验方案 奖励和建设的初步工作，从以前的补充，拟议的工作将 实现以下具体目标。具体目标1将调查耳鸣之间的关系 ADRD患者的认知功能。我们预测，耳鸣的严重程度将与 认知能力下降具体目标2将使用电脑刺激治疗耳鸣在相同的 患者主要假设是，与典型的非ADRD受试者相比， 将需要不同的电刺激参数以实现最佳耳鸣抑制。我们预测 动态脑电刺激将比稳态耳电刺激更有效， 抑制ADRD受试者的耳鸣。锡的表征可以作为生物标志物， 监测ADRD的发作和进展，而耳鸣抑制可能会延迟或减少 认知能力下降和ADRD的发展。 研究策略

Principal Investigator/Program Director (Last, first, middle): Zeng, Fan-Gang ABSTRACT The present administrative supplement proposes to examine the relationship between tinnitus and cognition and to treat tinnitus in patients with Alzheimer's disease and related dementia (ADRD). Tinnitus is a hearing disorder that produces auditory perception without auditory stimulation and affects 13-52% of the ARDR population. Using the same experimental protocols as in the active parent award and building upon the preliminary work from a previous supplement, the proposed work will achieve the following specific aims. Specific Aim 1 will investigate the relationship between tinnitus and cognition in ADRD patients. We predict that tinnitus severity will be positively correlated with cognitive decline. Specific Aim 2 will use electric brain stimulation to treat tinnitus in the same patients. The main hypothesis is that, compared with typical non-ADRD subjects, the ADRD patients would require different electric stimulation parameters for optimal tinnitus suppression. We predict that dynamic brain electric stimulation will be more effective than steady-state ear electric stimulation in suppressing tinnitus in ADRD subjects. Tinnitus characterization may serve as a biomarker for monitoring the onset and progression of ADRD, while tinnitus suppression may delay or reduce cognitive decline and development of ADRD. Research Strategy