T cells in Childhood Obesity: Immunometabolic Phenotype and Effects of Metformin

该应用程序的目标是开发一个综合的，跨学科的和翻译中心， 儿童肥胖症的预防儿童肥胖是一个国家公共卫生威胁， 在阿肯色州更糟。因此，当前的目标是防止阿肯色州儿童肥胖率的上升， 最终目标是将我们州的儿童肥胖率降低≥10%（降低约3.8%）， 未来5-10年。通过建立该中心，我们将通过协调一致、 以社区为基础的方法，针对可改变的个人风险行为，环境风险因素，以及当地， 州和国家减少风险政策。这一策略将包括调查潜在的代谢因素。 我们将汇集一组四个有前途的初级研究人员，他们的集体研究重点是 这一中心主题的多个方面为这些调查人员提供了支持性的基础设施环境 专门开发，以提高他们的成功机会，并利用这一初步提供的基础， 该小组将再培养4名后备初级调查员，并推动正在进行的初级调查员征聘工作。 随后的初级研究人员对以社区为基础的儿童肥胖方法感兴趣 预防具体目标#1将建立儿童肥胖预防中心， 儿童肥胖症通过有针对性的行为，环境和政策。在具体目标#2中，我们将 协调和加强现有的研究基础设施，并在ACHRI和UA之间开展合作 支持中心的系统。将建立或加强三个核心， 中心研究者：行政和科学支持核心A，生物统计学和信息学核心B， 和代谢核心C，每个都在经验丰富的高级教师的领导下，具有强大的研究和 行政背景。指导计划将包括中心指导委员会（CMC） 其中包括两名高级教员，与每个初级研究员和每个管道相匹配 调查员（共11人;有些重叠）;此外，UAMS教师发展计划（FDP）支持 通过晋升和终身教职促进初级教师的一般学术职业发展和进步 过程这些战略与现有的高级研究学院的专门知识和 内部执行委员会，将提供协同作用和监督所需的发展进行中 成功的外部应用程序，以维持这项工作。

The goal of this application is to develop an integrated, interdisciplinary and translational Center for Childhood Obesity Prevention. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. Therefore, the immediate goal is to prevent the rise in Arkansas childhood obesity rates, with an ultimate goal of reducing childhood obesity rates by ≥10% (reduction of ~3.8%) in our state over the next 5-10 years. Through the establishment of the Center, we will meet this critical need through a coordinated, community-based approach targeting modifiable individual risk behaviors, environmental risk factors, and local, state and national risk reduction policies. This strategy will include investigation of underlying metabolic factors. We will bring together a group of four promising junior investigators whose collective research focuses on multiple aspects of this central theme, provide these investigators with a supportive infrastructure environment developed specifically to enhance their chances for success, and use the foundation provided by this initial group to develop four additional pipeline junior investigators, as well as to promote ongoing recruitment of subsequent junior investigators with an interest in community-based approaches to childhood obesity prevention. Specific Aim #1 will establish the Center for Childhood Obesity Prevention, addressing childhood obesity through targeted behaviors, environments, and policies. In Specific Aim #2, we will coordinate and enhance existing research infrastructure and collaboration throughout the ACHRI and the UA System in support of the Center. Three cores will be established or enhanced to support the research of Center investigators: an Administrative and Scientific Support Core A, a Biostatistics and Informatics Core B, and a Metabolism Core C, each under the leadership of experienced senior faculty with strong research and administrative backgrounds. The mentoring program will consist of the Center Mentoring Committee (CMC) which includes two senior faculty members matched with each junior investigator and each pipeline investigator (11 total; some overlap); further, the UAMS Faculty Development Program (FDP) supports the general academic career development and advancement of junior faculty through the Promotion and Tenure process. These strategies, in coordination with the expertise of the established senior research faculty and an internal Executive Committee, will provide the synergy and oversight required for the development of ongoing successful external applications to sustain this work.