Nebraska Center for Molecular Target Discovery and Development

项目概要/摘要：总体中心组织和管理计划 内布拉斯加分子靶点发现和开发中心的目标是建立和扩大 内布拉斯加大学医学中心（UNMC）和内布拉斯加大学医学中心（UNMC）的物质和智力资源 内布拉斯加州的系统，将催化其教师的能力，以定义，验证和开发潜在的疗法 针对临床重要疾病的分子靶点。该中心旨在最大限度地提高双方的投资 COBRE奖和UNMC，以提高该机构的研究能力，扩大翻译 其教师的能力，促进有前途的初级教师在目标领域的职业发展 治疗，并有效地推动发现和发展，以改善人类健康， 内布拉斯加州和全国。该中心将（1）为发现和验证以下内容创建关键基础设施： 对疾病发展至关重要的分子效应器，以及（2）为有前途的 新的研究人员愿意并能够使用该基础设施来验证这些效应器作为治疗靶点， 鉴定小分子用于它们的操作，并创建用于它们的体外和体内临床前模型。 开发新的治疗方法。中心调查人员带来了必要的尖端专业知识的广度， 实现这一愿景。他们有一个共同的信念，即许多疾病可以有效地分类， 通过详细的基因组、遗传和分子分析来确定驱动因素和脆弱性， 从中将产生独特的治疗方法。为了实现这一共同愿景，中心及其 调查人员将：1）建立一个管理核心和指导计划，以支持和加强 目标发现和开发研究; 2）建立一个关键的调查人员质量， 用于疾病治疗的治疗靶点的鉴定、验证和开发;以及3）增加 通过高通量化学、RNA干扰和计算筛选的科学核心进行研究; 质谱法;和目标验证。

Project Summary/Abstract: Overall Center Organization and Management Plan The goal of the Nebraska Center for Molecular Target Discovery and Development is to establish and expand physical and intellectual resources at the University of Nebraska Medical Center (UNMC) and the University of Nebraska system that will catalyze the ability of its faculty to define, validate, and develop potential therapies against molecular targets for clinically important diseases. The Center aims to maximize investment from both the COBRE award and UNMC to enhance the research capabilities of the Institution, expand the translational capabilities of its faculty, facilitate career advancement of promising junior faculty in the area of targeted therapeutics, and efficiently drive discovery and development for the improvement of human health in Nebraska and the nation. This Center will (1) create critical infrastructure for the discovery and validation of molecular effectors critical to the development of disease and (2) deliver training and mentoring to promising new investigators willing and able to use that infrastructure to validate those effectors as therapeutic targets, identify small molecules for their manipulation, and create in vitro and in vivo preclinical models for their development as novel therapies. Center investigators bring a breadth of cutting edge expertise necessary to accomplish this vision. They share a common belief that many diseases can be effectively classified and characterized through detailed genomic, genetic, and molecular analyses to identify drivers and vulnerabilities from which will emerge unique therapeutic approaches. To realize this shared vision, the Center and its investigators will: 1) Establish an Administrative Core and mentoring programs to support and enhance research in target discovery and development; 2) Establish a critical mass of investigators focused on the identification, validation and development of therapeutic targets for disease treatment; and 3) Increase research capacity through scientific cores for high throughput chemical, RNAi and computational screening; mass spectrometry; and target validation.