检测 TBI 后突触连接的破坏和恢复-猫眼课题宝

检测 TBI 后突触连接的破坏和恢复

批准号：

10092458

负责人：

MARK P BURNS

金额：

$38.71万

依托单位：

GEORGETOWN UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-04-15 至 2023-08-31

来源：

https://reporter.nih.gov/project-details/10092458

关键词：

Acute Adult Aging Animal Model Animals Architecture Area Award Behavior Behavioral Biochemistry Biology Brain Contusions Burn injury Chronic Clinical Data Analyses Data Collection District of Columbia Electrophysiology (science)Ensure Event Functional Magnetic Resonance Imaging Functional disorder Goals Guidelines HIV Seropositivity Heterogeneity Hippocampus (Brain)IACUC Image Impaired cognition Impairment Individual Differences Inflammation Injury Intervention Learning Long-Term Potentiation Magnetic Resonance Imaging Measures Memory Methods Modeling Molecular Biology Morphology Mus Neuronal Dysfunction Neurons Outcome Patients Pattern Phase Procedures Protocols documentation Recovery Regression Analysis Reporting Research Research Design Research Personnel Severities Statistical Data Interpretation Synapses Techniques Technology TimeLine Traumatic Brain Injury Traumatic Brain Injury recovery Validation Work animal tissue axon injury base behavioral outcome blind cognitive ability cognitive function controlled cortical impact data sharing fluid percussion injury functional MRI scan head impact improved mild traumatic brain injury multidisciplinary neural network neurobehavior neuroinflammation neuron loss neuronal circuitry novel outcome prediction preference receptor response synaptic function tau aggregation tau-1

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中文摘要

翻译

项目摘要这个提议的基本原理是突触的完整性对神经元功能至关重要。中断突触完整性是常见TBI病理生理学事件的下游，轴突损伤、p-tau聚集和神经炎症。检测突触中离散变化的能力完整性--无论突触丢失的上游机制如何--将使临床医生能够跟踪临床干预，以改善患者的慢性结局。这项建议的目的是利用措施，的突触完整性，以预测慢性行为结果，并验证Hcorr作为一种非侵入性的标记物，用于TBI的突触完整性。

英文摘要

PROJECT SUMMARY The rationale for this proposal is that synaptic integrity is essential for neuronal function. Disruptions to synaptic integrity are downstream of common TBI pathophysiological events including neuronal cell death, axonal injury, p-tau aggregation, and neuroinflammation. The ability to detect discrete changes in synaptic integrity – regardless of the upstream mechanism of synapse loss – will allow clinicians to track the ability of clinical interventions to improve chronic outcome in patients. The objective of this proposal is to use measures of synaptic integrity to predict chronic behavioral outcomes, and to validate Hcorr as a non-invasive marker of synaptic integrity for use in TBI.

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