AOD Use Trajectories from Age 10 to 24: Multi-level Predictors, Health, and Behavioral Functioning, and Racial/ethnic Disparities

摘要/摘要 本行政副刊响应NOT-OD-20-032；特别关注通知：行政 性和性别少数群体(SGM)研究补充资料。酒精及其他药物(AOD) 使用是性少数群体和性别少数群体之间健康和其他功能差异的重要因素 (SGM)。与非SGM个人相比，一些SGM个人，特别是年轻人更有可能使用AOD 同伴们。先前的工作已经报告了性别歧视和非性别歧视年轻人之间的功能差异，以及 这些组之间AOD使用的纵向模式的差异。然而，很少有研究讨论如何 青春期和成年初期使用AOD的发展轨迹可能有助于 特别是在多个职能领域出现性别平等现象(例如， 学术和职业功能；社会功能)。例如，人们对以下方面知之甚少 这些重要发育期的AOD使用轨迹是否会不成比例地影响 SGM患者的结局，或者哪些功能领域可能在年轻人中受到不同的影响 成人期。鉴于各种不同领域可能会出现差异，评估AOD- 跨多个功能领域的相关差异，以更好地理解这些负面结果是如何 可能表现在SGM个人身上。此外，有证据表明，SGM的亚群可能与 关于AOD的使用模式，但很少有研究涉及AOD相关功能的出现 小岛屿发展中国家内部的差异(例如，按种族/族裔划分)。拟议的补充研究将利用现有的 来自正在进行的关于成人过渡期间AOD使用种族多样性的研究的纵向数据 (STARTRAN；R01AA025848)来解决这些差距。丰富的、人口结构多样化的地层数据集将允许 美国将评估不同类型的AOD使用(酒精、大麻和其他药物)和结果 具有大的纵向样本的区域。研究目标是：目标1.检查AOD使用的轨迹(即， 酒精、大麻和其他非法药物；在不同的模型中进行检查)从青春期早期开始的11年 通过青春期预测SGM青壮年多个领域的功能：1) 危险行为(例如性冒险、犯罪)，2)身体健康，3)精神健康，4)社交 /关系功能，5)学习功能，6)职业功能；目标2.确定 是否存在差异，通过评估AOD使用轨迹是否与 SGM与非SGM同龄人在青年时期的功能；以及目标3.在SGM内，评估 AOD使用轨迹在不同种族/民族群体(即种族/民族差异)之间预测结果不同 在SGM内)和性别。研究结果将为AOD相关疾病的出现提供关键信息 此外，还可为减少AOD相关危害的预防和干预工作提供信息。

Summary/Abstract This administrative supplement responds to NOT-OD-20-032; Notice of Special Interest: Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations. Alcohol and other drug (AOD) use is a significant contributor to health and other functional disparities among sexual and gender minorities (SGMs). Some SGM individuals, particularly young adults, are more likely to use AOD compared to non-SGM peers. Prior work has reported on functional disparities across SGM and non-SGM young people, as well as differences in longitudinal patterns of AOD use across these groups. However, few studies have addressed how developmental trajectories of AOD use during adolescence and emerging adulthood may contribute to the emergence of disparities for SGM young adults, especially across multiple domains of functioning (e.g., academic and occupational functioning; social functioning). For example, very little is known regarding whether trajectories of AOD use during these important developmental periods may disproportionately affect outcomes for SGM individuals, or which domains of functioning may be differentially affected in young adulthood. Given that disparities may appear across a variety of different domains, it is crucial to assess AOD- related disparities across multiple domains of functioning to better understand how these negative outcomes may manifest for SGM individuals. Additionally, evidence suggests that subgroups of SGMs may differ with respect to patterns of AOD use, yet little research has addressed the emergence of AOD-related functional disparities within SGMs (e.g., by race/ethnicity). The proposed supplement research will utilize existing longitudinal data from the ongoing STudy of Racial diversity in AOD use during the Transition to Adulthood (STRATA; R01AA025848) to address these gaps. The rich, demographically diverse STRATA dataset will allow us to assess different types of AOD use (alcohol, marijuana, and other drugs) and outcomes across multiple domains with a large longitudinal sample. Study aims are: Aim 1. Examine trajectories of AOD use (i.e., alcohol, marijuana, and other illicit drugs; examined in separate models) over 11 years from early adolescence through young adulthood as predictors of functioning across multiple domains within SGM young adults: 1) risk behaviors (e.g., sexual risk-taking, delinquency), 2) physical health, 3) mental health, 4) social /relationship functioning, 5) academic functioning, and 6) occupational functioning; Aim 2. Determine whether disparities exist by assessing whether trajectories of AOD use are differentially associated with functioning in young adulthood for SGM versus non-SGM peers; and Aim 3. Within SGMs, assess whether AOD use trajectories differentially predict outcomes across racial/ethnic groups (i.e., racial/ethnic disparities within SGM) and sex/gender. Study findings will provide critical information on the emergence of AOD-related disparities for SGMs and can inform prevention and intervention efforts to reduce AOD-related harms.