Research Methods in Pediatric Cardiovascular Disease

摘要 儿科心血管疾病科研培训计划的目标是吸引和培养高素质人才 合格的MD、MD-PhD和博士科学家致力于促进了解、诊断、治疗、 以及预防儿科和先天性心脏病。该计划的总部设在 波士顿儿童医院(BCH)的心脏病学，国内和国际领先的儿科中心 先天性心脏病的心脏病学和治疗。这份T32中的34位教师导师包括杰出的 和高度合作的科学家-来自BCH、哈佛医学院(HMS)及其附属机构 医院和麻省理工学院-拥有与儿科相关的基础、翻译和临床研究方面的专业知识 心血管疾病。今年，他们总共持有3490万美元的支持资金。在中受支持的 在过去的15年里，91%的人仍然活跃在研究领域，76%的人继续从事学术研究，18%的人来自 有代表性的团体。研究培训执行委员会(RTEC)，由计划主任组成 和四位现任导师，将监督伙伴培训、职业发展和指导的进展， 批准新的导师，并确保现有导师符合培训计划的指标。我们是 请求8个实习生职位，平均支持4个医学博士或医学博士学位和4个医学博士学位的培训 每年都有博士学位。参加T32培训计划的竞争非常激烈-来自我们才华横溢的 候选者池，约7%被选为T32支持。我们将让学员了解临床、翻译或基础知识 代表当前技术水平的研究技术。核心课程将包括以下培训 生物统计学、工作进行中会议、心血管研讨会系列、实践教学系列 心脏解剖和职业发展研讨会。受训人员还将参加年度务虚会和 T32学员和导师参加的定期会议。通过这些交流，面向临床 学员将获得对基础心血管生物学的了解，基础科学学员将获得 了解重要的临床问题。该计划允许学员进一步调整他们的培训，以 具体的研究兴趣，通过利用正规课程和 在BCH、HMS、哈佛公共卫生学院和麻省理工学院举办了无数的科学研讨会和讲座。我们 还教导学员团队合作的重要性，清楚地沟通研究结果，负责任 进行人类和实验室研究，以及指导技能。学员进步的里程碑和衡量标准 培训计划本身也有概述，并将由RTEC进行监督。相当多的机构 支助包括补充实习生津贴和旅费，以及对东非共同体和方案的支助 活动。在严格的实验台研究、翻译和临床方面进行了出色的培训 在一个互动和充满活力的项目中进行调查将为毕业生成为儿科领域的领导者做好准备 心脏病学和心血管研究。

ABSTRACT The goal of the Research Training Program in Pediatric Cardiovascular Disease is to attract and train highly qualified MD, MD-PhD, and PhD scientists dedicated to advancing the understanding, diagnosis, treatment, and prevention of pediatric and congenital heart disease. The program is based in the Department of Cardiology at Boston Children’s Hospital (BCH), a leading national and international center for pediatric cardiology and treatment of congenital heart disease. The 34 Faculty Mentors in this T32 include outstanding and highly collaborative scientists - drawn from BCH, Harvard Medical School (HMS) and its affiliated hospitals, and MIT - with expertise in basic, translational, and clinical research relevant to pediatric cardiovascular disease. Together, they hold $34.9M in total support for the current year. Of those supported in the past 15 years, 91% remain active in research, 76% continue in academia, and 18% are from under- represented groups. A Research Training Executive Committee (RTEC), comprising the Program Directors and four current mentors, will oversee the progress of fellow training, career development, and mentoring, approve new mentors, and ensure that existing mentors meet the metrics of the training program. We are requesting 8 trainee positions, on average supporting the training of 4 with MD or MD-PhD degrees and 4 with PhD degrees each year. Entry into the T32 training program is highly competitive – from our highly talented candidate pool, ~7% are selected for T32 support. We will expose trainees to the clinical, translational, or basic research techniques that represent the current state of the art. A Core Curriculum will include training in biostatistics, Work-in-Progress meetings, a cardiovascular seminar series, a hands-on didactic series in cardiac anatomy, and career development seminars. Trainees will also participate in an annual retreat and regular meetings attended by T32 trainees and mentors. Through these interchanges, clinically-oriented trainees will gain understanding of fundamental cardiovascular biology, and basic science trainees will gain understanding of important clinical problems. The program allows trainees to further tailor their training to specific research interests by taking advantage of the stellar opportunities for formal coursework and the myriad of scientific seminars and lectures at BCH, HMS, the Harvard School of Public Health, and MIT. We also teach trainees the importance of teamwork, the clear communication of research findings, responsible conduct of human and laboratory research, and mentoring skills. Milestones and metrics for trainee progress and the training program itself are outlined and will be overseen by the RTEC. Considerable institutional support includes supplementation of trainee stipends and travel funds, and support for the EAC and program activities. Excellent training in rigorous experimental bench research and in translational and clinical investigation within an interactive and vibrant program will prepare graduates to become leaders in pediatric cardiology and cardiovascular research.