Research and career training in vertebrate developmental genomics

描述（由申请人提供）：要求资金支持脊椎动物发育基因组学的综合培训计划。该项目将在康奈尔大学脊椎动物基因组学中心（CVG）的管理下进行，该中心是一个拥有全校教职工代表的行政单位。该计划将在任何时候重点培养三名博士生，他们已经选择了一名论文导师，并完成了一个强制性学期的助教工作。该计划将强调多学科和比较方法来研究发育基因组学。因此，17名经验丰富、坚持这些原则的教员将担任培训人员。他们代表了广泛的专业知识，包括经典发育生物学、功能基因组学、发育遗传学、复杂性状、统计遗传学和计算基因组学。他们的研究主要集中在脊椎动物，包括老鼠、斑马鱼、狗、马和人类，但也有代表秀丽隐杆线虫和果蝇。他们还在脊椎动物发育和疾病的几个重要领域提供专业知识，包括神经生物学、生殖生物学、干细胞、器官发生、心脏病和功能、染色质结构和功能、早期胚胎植入后发育、宫内胎儿发育和疾病、衰老、发育进化、表观遗传学、营养基因组学以及癌症。为了准备NIH支持的项目，CVG在大学种子的支持下开发了培训范例和基础设施。二年级及以上的研究生将从校园现有的几个研究生领域中挑选。选择将基于学生的学术和研究承诺，优先考虑进行合作或多学科研究的学生。学员将被要求获得基因组学的辅修学位，并参加与培训主题相关的一些活动，包括学生/同事组织的脊椎动物基因组学杂志俱乐部；发育生物学杂志俱乐部；“VERGE”（脊椎动物基因组学）研究系列；CVG年度专题讨论会；CVG年度电子海报会议；以及相关的外部会议和课程。除论文委员会外，还将由培训委员会监督学生的选拔和进度。这个拟议的项目将在康奈尔大学新的生命科学计划的背景下进行，这是其历史上最大的努力。再加上致力于培养学术研究人员的卓越传统和脊椎动物基因组学的有针对性的机构支持，该计划将为学员提供良好的环境。

DESCRIPTION (Provided by Applicant): Funding is requested to support a comprehensive training program in Vertebrate Developmental Genomics. The program will be conducted under the umbrella of Cornell University's Center for Vertebrate Genomics (CVG), an administrative unit with University-wide faculty representation. This proposed program will focus on training, at any one time, three predoctoral students who have chosen a thesis advisor and have finished one mandatory semester of teaching assistantship. The program will emphasize multidisciplinary and comparative approaches to studying developmental genomics. Accordingly, seventeen experienced faculty, who adhere to these tenets, will serve as trainers. They represent a gamut of expertise, including classical developmental biology, functional genomics, developmental genetics, complex traits, statistical genetics, and computational genomics. Their research concentrates primarily on vertebrate organisms, including mice, zebrafish, dog, horse, and humans, but also represented are C. elegans and Drosophila. They also provide expertise in several important areas of vertebrate development and disease, including neurobiology, reproductive biology, stem cells, organogenesis, heart disease & function, chromatin structure & function, early postimplantation development, intrauterine fetal development and disease, aging, evolution of development, epigenetics, nutritional genomics, as well as cancer. In preparation for an NIH supported program, the training paradigm and infrastructure has been developed by the CVG with University seed support. Graduate students in their 2nd year and beyond will be selected from several existing graduate fields across campus. Selection will be based upon academic and research promise of the student, with a preference for those conducting collaborative or multidisciplinary research. Trainees will be required to obtain a minor degree in Genomics, and participate in several activities related to the training theme, including the student/fellow-organized Vertebrate Genomics Journal Club; the Developmental Biology Journal Club; the "VERGE" (Vertebrate Genomics) research series; the annual CVG symposium; the annual CVG electronic poster session; as well as relevant external conferences and courses. Selection of students and monitoring of their progress will be overseen by a training committee, in addition to their thesis committee. This proposed program will take place in the context of Cornell University's new Life Sciences Initiative, the largest effort in its history. Coupled with an exceptional tradition of dedication to training academic researchers and targeted Institutional support for Vertebrate Genomics, this program will provide an outstanding environment for trainees. RELEVANCE: Critical to the understanding of disease and birth defects is a solid comprehension of the underlying molecular and genetic mechanisms of development. These basic mechanisms have been elucidated through the study of many powerful model organisms and extrapolated to humans. This program will provide trainees with a comprehension and appreciation of the important problems in animal development, and experience in using state-of-the-art genomics tools to address new frontiers in this area.