Real-Time Digital Autoradiography System

描述(由申请人提供)：这项共享仪器赠款建议用于购买具有多种放射标签能力的数字、实时放射自显影系统。NIH资助的需要该系统的研究项目主要旨在开发新的分子成像剂，并验证现有的放射性示踪剂，用于研究基本的生物过程和评估治疗干预的影响。该系统将设在小动物成像中心(CSAI)，与代表主要活体成像方式(超声波、生物发光/荧光、X射线CT、PET、SPECT、MRI和MRS)的系统一起安装。CSAI还有一个冷冻切片切割机，可以方便地为放射自显影准备组织切片。放射自显影能力对许多研究的一个关键好处是有机会获得高分辨率的定量数据，以帮助解释和验证体内成像指标。CSAI是该大学的核心机构，是范德比尔特大学成像科学研究所的一部分。放射自显影系统将由一群经验丰富的成像科学家和一支高素质的支持人员提供支持。它也将是我们在癌症成像方面的机构培训计划以及我们在成像科学方面的其他培训人员支持的博士后培训人员的关键资源。

DESCRIPTION (provided by applicant): This shared instrumentation grant proposal is for the purchase of a digital, real-time autoradiography system with multiple radiolabel capability. The NIH-funded research projects that require this system are aimed primarily at developing new molecular imaging agents and validating existing radiotracers for the investigation of fundamental biological processes and the assessment of the impact of therapeutic interventions. The system will be located in the Center for Small Animal Imaging (CSAI) alongside systems representing the major in vivo imaging modalities (ultrasound, bioluminescence/fluorescence, X-ray CT, PET, SPECT, MRI and MRS). The CSAI also has a cryo-microtome that will facilitate the preparation of tissue slices for autoradiography. A key benefit of the autoradiography capability to many of the studies will be the opportunity to obtain high-resolution, quantitative data to assist in the interpretation and validation of in vivo imaging metrics. The CSAI functions as a Core Facility for the university and operates as part of the Vanderbilt University Institute of Imaging Science. The autoradiography system will be supported by an experienced group of imaging scientists and a highly qualified support staff. It also will be a key resource for postdoctoral trainees supported by our institutional training program in cancer imaging as well as our other trainees in imaging science.