Training program in vaccine development

说明（由申请人提供）：理由和相关性：在发展中国家，传染病仍然是造成大量发病率和死亡率的原因。疫苗是医学上最具成本效益的进步之一，如果使用得当，是控制传染病的有力工具。成功的疫苗开发需要一种综合的科学和公共卫生方法，并需要基础科学家、流行病学家、公共卫生官员、临床医生、机构和监管机构以及工业界等的投入。开发安全有效的疫苗通常需要对感染过程的潜在发病机制以及宿主-病原体相互作用和免疫反应有明确的了解。目标：这一培训方案的主要目标是在ICDDR疫苗开发领域建立可持续的传染病研究能力。B：国际健康和人口研究中心，孟加拉国达卡。重点将是对个人进行培训，从根本上开发和评价预防肠道感染的疫苗，重点是开发和评价预防霍乱病菌霍乱弧菌的疫苗。特别强调的重点将包括高通量基因组和蛋白质组学技术在霍乱弧菌疫苗开发中的作用。在这些领域受过培训的个人将补充国际减灾会议已有的专门知识和技能。B，并将有助于在ICDDR建立一个协同的核心研究小组。B能够应对全球和发展中世界当前和持续的传染病威胁。设计：我们建议在麻省总医院-哈佛大学和ICDDR.B之间开展一项为期五年的疫苗开发全球传染病研究培训计划。培训方案将以两所机构的优势和一些正在进行的合作为基础，并将包括对一小群个人的强化和长期培训（在哈佛大学总医院一年；在国际发展与发展研究所两年）。B)，以及通过讲习班和研讨会对更多的个人进行更短期和更有重点的培训。B)与疫苗开发有关的话题。

DESCRIPTION (provided by applicant): Rationale and Relevance: Infectious diseases still account for significant morbidity and mortality in the developing world. Vaccines are one of the most cost effective advances in medical science, and if appropriately used, are potent instruments in the control of infectious diseases. Successful vaccine development requires an integrative scientific and public health approach, and requires input from basic scientists, epidemiologists, public health officials, clinicians, institutional and regulatory agencies, and industry, among others. The development of a safe and effective vaccine most often requires a firm understanding of the underlying pathogenesis of the infectious process, as well as host-pathogen interactions and immune responses. Objectives: The main objective of this training program is to build sustainable infectious disease research capacity in the field of vaccine development at the ICDDR.B: International Centre for Health and Population Research, Dhaka, Bangladesh. The focus would be the training of individuals in the fundamental development and evaluation of vaccines against enteric infections, focusing on the development and evaluation of vaccines against Vibrio cholerae, the cause of cholera. Special emphasis would include the role of high throughput genomic and proteomic technologies in V. cholerae vaccine development. Individuals trained in these areas would complement the expertise and skills already present at the ICDDR.B, and would help create a synergistic core group of researchers at the ICDDR.B able to meet current and ongoing infectious disease threats globally and in the developing world. Design: We propose a five year Global Infectious Disease Research Training Program in vaccine development between the Massachusetts General Hospital-Harvard University and the ICDDR.B. The training program would build upon the strengths of both institutions and a number of on-going collaborations, and would include both intensive and long-term training of a small group of individuals (one year at the MGH- Harvard; two years at the ICDDR.B), as well as shorter and more focused training of a larger group of individuals through workshops and seminars (at the ICDDR.B) on topics pertinent to vaccine development.