TROPICAL INFECTIOUS DISEASE TRAINING GRANT

描述（由申请人提供）：巴伊亚联邦大学免疫学处正在与美国和其他巴西机构合作开展关于地方性热带病（利什曼病、血吸虫病、HTLV-1）的研究项目，旨在：1)表征对这些病原体的免疫反应，2)将免疫反应与这些疾病的临床表现联系起来，3)研究遗传对疾病结局的贡献，4)确定新的治疗和控制措施，5)确定干扰疾病结局的病原体成分。巴伊亚联邦大学过去利用了与康奈尔大学的合作，在福加蒂资助的培训项目中培训年轻的研究人员。虽然免疫学服务得到了研究支持（包括TMRC， NIH拨款），但没有具体的支持来解决实施这些项目所需的培训需求。本提案将利用利什曼病研究中确定的需求来实现以下具体目标：1)在遗传学、疾病发病机制、临床调查和伦理等领域创造培训机会；2)向巴伊亚州和巴西其他大学的其他研究人员提供培训。为了实现第一个目标，该项目强调与国外大学（康奈尔大学、爱荷华大学、约翰霍普金斯大学、宾夕法尼亚大学、剑桥大学）合作，长期培养博士后（共5人）和短期培养青年和高级研究人员（共5人），以满足特定领域专业知识的具体需求。第二个目标将通过利用国内专门知识和资源以及受过高级培训的导师，在基础和临床免疫学、免疫疗法、分子和临床流行病学等领域以及在巴西导师培训后上述指定的新领域为研究生、研究生、青年研究人员、医生和技术人员提供培训来实现。

DESCRIPTION (provided by applicant): The Immunology Service of the Federal University of Bahia has ongoing research programs on endemic tropical diseases (leishmaniasis, schistosomiasis, HTLV-1) in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune response to these pathogens, 2) Correlating immunological response with clinical manifestations of these diseases, 3) Studying genetic contributions to disease outcome, 4) Identifying new forms of therapy and control measures, and 5) Identifying pathogen components that interfere in disease outcome. The Federal University of Bahia has taken advantage of its collaboration with Cornell University in the past, through training of young investigators in Fogarty-sponsored Training Programs. Although the Immunology Service receives support for research (including a TMRC, NIH grant), there is no specific support for addressing training needs required to implement these projects. The present proposal will use needs identified in the studies of leishmaniasis to address the following specific aims: 1) To create training opportunities in areas such as genetics, disease pathogenesis, clinical investigation and ethics, 2) To disseminate training to other investigators from Bahia and other universities of Brazil. To address the first aim this program emphasizes collaboration with foreign universities (Cornell University, University of Iowa, Johns Hopkins, University of Pennsylvania, Cambridge University) for longterm training of post-doctoral fellows (total of 5) and short-term advanced training for young and senior investigators (total of 5) to address the specific needs in expertise within the specified areas. The second aim will be addressed by using the in-country expertise and resources and the advanced trained mentors to provide training for graduate, post-graduate students, young investigators, physicians and technicians in areas such as basic and clinical immunology, immunotherapy, molecular and clinical epidemiology, as well as in the new areas specified above after the training of the Brazilian mentors.