Cell Signaling of Host Defense

由迈克尔·B·费斯勒医学博士领导的国家环境卫生科学研究所内壁研究部呼吸生物学实验室的宿主防御小组现在进入NIEHS的第14个年头。自上次年度报告以来出版的出版物包括： 1.一篇关于慢性肾脏疾病中巨噬细胞天然免疫的合作综述文章 2.关于蛋白溶质载体家族37成员2(Scl37a2)在巨噬细胞炎症和细胞代谢中作用的合作报告 3.关于胆固醇25-羟基酶在肺部炎症消退中的作用的资深作者出版物。 4.关于microrna-33在抗病毒宿主防御中的作用的特邀社论 5.关于慢性阻塞性肺疾病问卷定义有效性的合作报告 6.先天免疫受体TLR5在环境肺损伤中作用的研究报告 7.巨噬细胞自噬在小鼠动脉粥样硬化中的作用 8.描述双酚A替代品(双酚F和S)与人类哮喘和花粉热之间关系的合作报告 9.一份资深作者报告描述了瑞舒伐他汀对血清胆固醇正常的志愿者免疫系统的影响。 10.一份资深作者出版物描述了上皮膜蛋白2在控制中性粒细胞进入受感染肺中的新作用。 自我们上次报告以来的其他成就包括，Fessles博士因建议创建跨NIH代谢组学和脂质组学联盟以协调和推进内部代谢组学研究而获得NIH董事挑战创新奖。Fessler博士还被任命为佛蒙特州肺脏中心外部咨询计划的成员，并在今年夏天早些时候参加了VLC的一次虚拟务虚会，为他们的研究计划提供专家反馈。费斯勒博士继续担任《美国呼吸细胞和分子生物学杂志》的副主编。费斯勒博士和他的学员在过去一年的几次会议上，以口头陈述和海报的形式展示了他们的研究成果。此外，Fessler博士中的两位博士后研究员林婉琪博士和Prashant Rai博士获得了NIH杰出研究员奖。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 14th year at the NIEHS. Publications since the last annual report include: 1. a collaborative review article on macrophage innate immunity in chronic kidney disease 2. a collaborative report on the role of the protein Solute Carrier Family 37 Member 2 (SCL37A2) in macrophage inflammation and cellular metabolism 3. a senior-author publication on the role of the enzyme cholesterol 25-hydroxylase in resolution of lung inflammation 4. an invited editorial on the role of microRNA-33 in antiviral host defense 5. a collaborative report on the validity of questionnaire-based definitions for chronic obstructive lung disease 6. a collaborative report on the role of innate immune receptor TLR5 in environment-induced lung injury 7. a collaborative report on the role of autophagy in macrophages in atherosclerosis in mice 8. a collaborative report describing the association of bisphenol A substitutes (bisphenols F and S) with asthma and hay fever in humans 9. a senior author report describing the effect of rosuvastatin on the immune system of volunteers who have normal serum cholesterol 10. a senior author publication describing a novel role for Epithelial Membrane Protein 2 in the control of neutrophil entry into the infected lung. Additional accomplishments since our last report include Dr. Fesslers receipt of the NIH Directors Challenge Innovation Award for his proposal to create a Trans-NIH Metabolomics and Lipidomics Consortium to coordinate and advance intramural metabolomics studies. Dr. Fessler was also appointed member of the Vermont Lung Center External Advisory Program and attended a virtual retreat of the VLC earlier this summer to provide them with expert feedback on their research program. Dr. Fessler has continued his work as Associate Editor for the American Journal of Respiratory Cell and Molecular Biology. Dr. Fessler and his trainees presented their research findings, in the form of oral presentations and posters, at several meetings over the past year. In addition, two of Dr. Fesslers postdoctoral fellows, Drs. Wan-Chi Lin and Prashant Rai, received NIH Fellows Awards for Research Excellence.