Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

这一续签申请寻求对多种族队列(MEC)研究的基础设施的支持，该研究是 1993-1996年在夏威夷和加利福尼亚州南部成立，研究癌症和其他慢性疾病的风险因素 疾病。这项研究旨在利用这两个地理区域的种族和文化多样性 这些领域，以及研究人员在营养、族裔/种族研究和遗传学方面的专门知识。它是最多的 存在不同种族的癌症队列。它通过补充积极的跟进实现了高成本效益 通过计算机链接到SEER的信息、生命统计、出院诊断、医疗索赔 数据、电子病历和地理空间信息。在基准线上，队列包括以下信息 215,000名男性和女性，几乎全部由五个族裔/种族人口组成：高加索人、日本人 美国人、夏威夷原住民、非裔美国人和拉丁美洲人。该资源后来被扩展为包括一个 来自约70,000名参与者的血液和尿液样本的预期生物库。中国的领导力 MEC需要高度互动的团队方法；调查人员已经充分证明了他们的 愿意分享数据/样本，并积极参与联合体。这份申请描述了我们的目标 在未来5年内维护和加强MEC的基础设施，以及计划 方法论研究。研究成果包括对理解两者的重大贡献 癌症的遗传和环境风险因素。描述我们的发现的280多篇论文已经在 在本赠款周期内出版。此外，在过去的20年里，已经建立了98项研究补助金 在MEC周围，超过75名学生和博士后研究员接受了这项研究的培训。这 赠款续期将使旨在评估的综合研究方案得以继续 癌症和其他常见慢性病的环境和遗传风险因素，利用 新方法，如基因组学、微生物学、加合物组学和代谢组学。MEC将允许 测试旨在确保预防方面的进展适用于美国主要国家的创新研究假设 少数民族/少数族裔。

This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by supplementing active follow-up information with computerized linkages to SEER, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective biorepository of blood and urine specimens from ~70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 280 papers describing our findings have been published during the current grant cycle. In addition, over the last 20 years, 98 research grants have been built around the MEC, and more than 75 students and postdoctoral fellows have been trained on the study. This grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating environmental and genetic risk factors for cancer and other common chronic diseases, taking advantage of new approaches, such as genomics, microbiomics, adductomics and metabolomics. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that progress in prevention applies to major US ethnic/racial minorities.