Research Project 1 Defining oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment

研究项目1总结 艾滋病毒感染者患癌症的风险增加。特别是对于那些由人类致癌病毒引起的 如EBV、HPV和KSHV。艾滋病是拉丁美洲国家的一个卫生问题， 阿根廷，即使在后HAART时代。关于艾滋病毒感染者患癌症的信息很少。 阿根廷的个人。此外，艾滋病恶性肿瘤的转化研究是一个传统上被忽视的领域 大多数阿根廷临床医生和肿瘤学家很少合作。最近的努力博士的融合。 迈阿密大学米勒医学院西尔维斯特综合癌症中心的梅斯里实验室 （UMMSM/SCCC）、IFIBYNE-乌巴-CONICET的Omar Coso博士和Fundación Huésped的Pedro Cahn博士 致力于艾滋病研究、诊断和预防的最负盛名的非政府组织聚集在这个联盟中 U54格式下的提案，包括其他高级知名研究人员和初级科学家在每一个 联合体组件。项目1的目的是"定义艾滋病相关病毒中的致癌信号网络， 癌症作为化学预防和治疗的目标。"该提案将利用各种战略， 分子、细胞水平，甚至通过动物模型来识别分子（主要是蛋白质和miRNA） 涉及病毒性癌症的发病，并研究其与艾滋病毒感染的关系，使用不同的 方法和针对不同的分子。被确定为引起 在项目2的帮助下，将在人体样本中研究通过实验室方法检测的癌症。关系 OGB核心将通过使用无偏见的技术，使研究能力进一步提高， 基因组分析，以及IHC技术，以获得高通量数据，将验证数据获得 实验室和提示新的问题到工作台，使可能解决的研究问题， 是几年前无法想象的。指导对这个项目至关重要。科索博士将 作为项目1的PI领导KS相关分子信号的研究。另一方面， 由于他在CE核心中的作用，他将监督Ana Raimondi博士，探索靶向mTORC 1的可能性 在HPV模型中。科索博士还将与他的前实习生朱利安·奈保尔博士合作，后者开发了一种新的 KSHV肿瘤发生的细胞和动物模型，在实验室进行实验，并指导 回到阿根廷后，他作为一名病毒肿瘤学家的科学生涯的未来发展。

Research Project 1 Summary HIV infected individuals have heightened cancer risk. Particularly for those caused by human oncogenic viruses such as EBV, HPV and KSHV. AIDS Malignancies are a sanitary problem for Latin American Countries as Argentina, even in the post HAART era. There is scant information regarding cancer among HIV-infected individuals in Argentina. Moreover, translational research in AIDS malignancies is an area traditionally neglected where most Argentinean clinicians and oncologists rarely collaborate. The recent convergence of efforts of Dr. Mesri laboratory at University of Miami Miller School of Medicine's Sylvester Comprehensive Cancer Center (UMMSM/SCCC), Dr.Omar Coso at IFIBYNE – UBA – CONICET and Dr. Pedro Cahn from Fundación Huésped the most prestigious ONG devoted to AIDS studies, diagnosis and prevention have converged in this consortium proposal under the U54 format, including other Senior Prestigious Researchers and Junior Scientists in every Consortium Component. Project 1 aims to “Define oncogenic signaling networks in AIDS-associated viral cancers as targets of chemoprevention and treatment.” The proposal will make use a variety of strategies at the molecular, cellular level and even through animal models to identify molecules (mainly proteins and miRNAs) implicated in the onset of viral cancers and investigate its relationship with HIV infection, using different approaches and targeting different molecules. Putative Molecules identified as responsible for the onset of cancer by laboratory approaches will be studied in Human Samples with the aid of Project 2. Relationship with the OGB Core will allow enhancement of the research capabilities a significant step further by using unbiased genomic analysis, as well as IHC techniques, to obtain high throughput data that will validate data obtained in the laboratory and prompt new questions into the bench making possible to address research questions that were unimaginable only a few years back. Mentoring is of paramount importance to this project. Dr Coso will lead the studies in KS related molecular signaling working as a PI to Project 1. On the other hand and combining with his role in the CE Core, he will supervise Dr Ana Raimondi, exploring the possibility of targeting mTORC1 in HPV models. Dr. Coso will also team with his former trainee Dr Julian Naipauer, who has developed a new cell and animal model of KSHV oncogenesis, conducting experiments in the laboratory and mentoring for the future development of his scientific career as a viral oncologist upon return to Argentina.