The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)

项目摘要 情绪和焦虑症将造成约16 x 109美元的生产力损失，占全球GDP的25%。 在接下来的20年里。饮食失调是最致命的精神疾病之一， 比精神分裂症、躁郁症和重度抑郁症的致死率高两到三倍。中心 基于神经科学的心理健康评估和预测（NeuroMAP）旨在提供（a）科学， (b)可操作的，以及（c）用于基于神经科学的创新研究的教育基础设施，以使用个人 在几个生物水平上的差异以及复杂的统计方法， 对情绪、焦虑和饮食失调的风险和结果进行有意义的预测。获奖者研究所 位于俄克拉荷马州塔尔萨的脑研究所（LIBR）是提供这种基础设施的理想场所，因为： 招募了年轻的研究人员，他们在科学生产力方面有着令人印象深刻的记录，（B）LIBR位于 毗邻中西部最大的精神病医院之一的桂冠精神病诊所和医院（LPCH） 为LIBR提供患者招募渠道的设施，以及（c）LIBR与 塔尔萨大学（TU）的计算统计学和俄克拉荷马州大学，塔尔萨（俄克拉荷马）的生物测定 research. NeuroMAP的具体目标是：（1）提供最先进的神经影像学和实验室 利用核心设施进行多层次评估的生物实验基础设施;（2） 为一组年轻的研究人员提供指导基础设施，以进行研究， 情绪或焦虑症患者的生物标志物和过程;（3）创造职业生涯 发展基础设施，以加速调查员从年轻调查员向成熟调查员的过渡 调查员;（4）建立一个业务基础设施，提供进行研究所需的工具 这些项目将使评估标准化，并为今后的试点项目提供一个数据库。NeuroMAP将 （a）行政核心（保卢斯）：建立必要的基础设施， 年轻研究人员的研究工作;（B）研究核心（Bodurka，蒂格，麦金尼）：提供 利用多层次方法（从细胞标志物到症状）来量化个体 差异并产生结果预测。该中心提出了5个不同的项目：（1）小脑的作用 在恐惧条件反射和灭绝。(Cha)导师：Amit Etkin，斯坦福大学;（2）预测暴露反应 使用内感受性习惯的神经和行为标志物治疗焦虑症（Feinstein） 导师：Murray Stein，UCSD;（3）抑郁症的内感受性功能障碍和食欲失调 （Simmons）导师：Luan Phan，伊利诺伊大学芝加哥分校;（4） 严重抑郁症（Savitz）导师：Mike欧文，加州大学洛杉矶分校;（5）功能障碍的内感受准确性， 神经性厌食症，（Khalsa）导师：沃尔特·凯，加州大学圣地亚哥分校。

Project Summary Mood and anxiety disorders will account for approximately $16 x 109 lost productivity or 25% of global GDP over the next 20 years. Eating disorders are among the deadliest psychiatric diseases and Anorexia Nervosa is two to three times more deadly than schizophrenia, bipolar and major depressive disorder. The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) aims to provide a (a) scientific, (b) operational, and (c) educational infrastructure for innovative neuroscience-based research to use individual differences on several biological levels together with sophisticated statistical approaches to generate clinically meaningful predictions of risk and outcomes for mood, anxiety, and eating disorders. The Laureate Institute for Brain Research (LIBR) in Tulsa, OK, is ideally placed to provide this infrastructure because: (a) LIBR has recruited young investigators with an impressive track record of scientific productivity, (b) LIBR is situated adjacent to the Laureate Psychiatric Clinic and Hospital (LPCH), one of the Midwest's largest psychiatric facilities that provides LIBR with a pipeline for patient recruitment, and (c) LIBR closely collaborates with the University of Tulsa (TU) on computational statistics and University of Oklahoma, Tulsa (OU) on bioassay research. The Specific Aims of NeuroMAP are: (1) To provide a state of the art neuroimaging and laboratory infrastructure to conduct biological experiments with multi-level assessments using core facilities; (2) To provide a mentoring infrastructure to a group of young investigators to conduct studies that identify predictive biological markers and processes for patients with mood or anxiety disorders; (3) To create a career development infrastructure to accelerate the investigator's transition from young investigator to established investigator; (4) To build an operational infrastructure that provides the tools necessary to conduct the research projects, standardize assessments and provide a data repository for future pilot projects. NeuroMAP will consists of: (a) an Administrative Core (Paulus): to establish the infrastructure necessary to expand the research efforts of the young investigators; (b) Research Core (Bodurka, Teague, McKinney): to provide the technical expertise to utilize multi-level approaches (from cell markers to symptoms) to quantify individual differences and generate outcome predictions. The Center proposes 5 different projects: (1) Cerebellar Role In Fear Conditioning And Extinction. (Cha) Mentor: Amit Etkin, Stanford; (2) Predicting Response To Exposure Therapy In Anxiety Disorders Using Neural And Behavioral Markers Of Interoceptive Habituation (Feinstein) Mentor: Murray Stein, UCSD; (3) Interoceptive dysfunction and Appetite Dysregulation in Depression (Simmons) Mentor: Luan Phan, University of Illinois Chicago; (4) Response To Inflammatory Challenge In Major Depressive Disorder (Savitz) Mentor: Mike Irwin, UCLA; (5) Dysfunctional Interoceptive Accuracy In Anorexia Nervosa, (Khalsa) Mentor: Walt Kaye, UCSD.