Core A: Administrative and Professional Development Core

行政和专业发展核心由Lucy Liw和Clifford Rosen领导， 科布雷项目的首席调查员。作为科布雷项目的领导者，我们的目标是促进 并支持科学生产力和协作，加强和协调我们的研究基础设施， 寻找和拓展科学专业知识，并积极监督和监测职业发展 程序。为了实现这些目标，这个核心将1)提供该领域的领导和科学专业知识 新陈代谢健康和疾病中间充质组织分化、信号和神经相互作用的研究 2)建立由初级调查人员组成的核心研究小组，并以科学和职业为支撑 导师，3)加强科学核心设施，以支持最先进的研究方法，以及4) 管理协作试点项目计划。科布雷由四个主题相关的项目组成， 每个项目负责人都有两名资深研究导师，他们都是该领域的专家。其他建议 网络包括一个由科学专家和经验丰富的项目组成的外部咨询委员会 领导，以及由生物医学研究领域的科学专家和利益攸关方组成的指导委员会 在缅因州。我们缅因州医疗中心的临床同事将提供翻译机会和 关于代谢、健康和疾病领域的临床挑战的重要观点和指导。至 支持我们初级调查人员和核心设施负责人的进步，我们致力于 支持课程、研讨会和创新科学家离职的专业发展资源 促进合作和培训的计划。所有这些战略都将支持项目和核心领导者 达到我们中心明确定义的基准。一个强有力的评估计划将会有所帮助 促进积极的长期结果。这一核心和整个计划的具体目标是： 具体目标1.提供领导、治理和咨询网络，建立新的科学 间充质祖细胞生物学和神经信号转导计划，以获得对 代谢健康和疾病的潜在机制。 具体目标2.提供项目和导师支持，以启动有前途的年轻人的职业生涯 这一科学计划中的研究人员，并帮助确保他们作为独立的科学家取得长期的科学成功 研究人员。 具体目标3.增强我们核心设施的能力，以支持我们的Cobre调查人员和 其他机构和外部研究人员，并鼓励创新的研究方法和新的 合作。 具体目标4.加强我们现有的、由Cobre支持的试点项目方案，将重点放在翻译 与代谢性疾病相关的机会。

The Administrative and Professional Development Core is led by Lucy Liaw and Clifford Rosen, the Principal Investigators of this COBRE program. Our goals as leaders of this COBRE program are to foster and support scientific productivity and collaboration, enhance and coordinate our research infrastructure, seek out and expand scientific expertise, and actively oversee and monitor a professional development program. To accomplish these goals, this Core will 1) provide leadership and scientific expertise in the area of mesenchymal tissue differentiation and signaling and neural interactions in metabolic health and disease, 2) establish a core research group consisting of junior investigators supported by scientific and career mentors, 3) enhance scientific core facilities to support state-of-the-art research methodologies, and 4) administer a collaborative pilot project program. The COBRE consists of four thematically linked projects, and each project leader has two senior research mentors who are experts in the field. Additional advisory networks include an External Advisory Committee consisting of scientific experts and experienced program leaders, and a Steering Committee composed of scientific experts and stakeholders in biomedical research in Maine. Our clinical colleagues at Maine Medical Center will provide translational opportunities and important perspective and guidance on clinical challenges in the areas of metabolic health and disease. To support the advancement of our junior investigators and core facility leaders, we have dedicated professional development resources to support courses, workshops, and an innovative scientist leave program to foster collaboration and training. All of these strategies will support project and core leaders in achieving the benchmarks that are clearly defined within our Center. A robust evaluation program will help promote positive long-term outcomes. The specific aims of this Core and the overall program are: Specific Aim 1. Provide the leadership, governance, and advisory network to establish a new scientific program in mesenchymal progenitor cell biology and neural signaling to gain novel insights into the mechanisms underlying metabolic health and disease. Specific Aim 2. Provide project and mentorship support to launch the careers of promising junior investigators within this scientific program and help ensure their long-term scientific success as independent researchers. Specific Aim 3. Enhance the capabilities of our core facilities to support our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations. Specific Aim 4. Enhance our existing, COBRE-supported pilot project programs to focus on translational opportunities related to metabolic disease.