Basic applications for total-body PET in oncology

摘要： 探险家联盟，通过变革性的R01和大量的商业 投资，已经开发了一台2米长的全身PET扫描仪。这种设备有可能显著地 通过以下方式改变PET的临床应用：(A)大幅减少扫描时间，(B)大幅 图像质量的改善，(C)管理活动的大幅减少和(D)全身覆盖率。 本提案旨在回答这一新设备提出的有关 当前临床肿瘤学的应用空间：(1)进行扫描以获得标准诊断的速度 使用全身PET的图像；(2)屏气PET是否可行；(3)扫描仪是否支持 放射性示踪剂使用减少25倍；(4)是否有必要将成像延迟到 注射后的时间点比目前的做法要晚(5)如果图像质量得到改善 使用标准注射剂量和扫描次数具有临床实用价值。 我们将从加州大学戴维斯分校的临床肿瘤学人群中招募360名受试者； 特别是，受肺癌、淋巴瘤和黑色素瘤影响的受试者最初进行PET/CT扫描 在开始治疗之前，将登记分期。 我们预计探索者全身PET扫描仪将能够进行类似的研究 在大约一分钟内或使用更小的剂量将诊断质量提高到传统的PET/CT扫描仪 相当于标准剂量的1/25。此外，我们预计屏气检查将是 在资源管理器上可行。我们还预测，在探测器上进行非常晚的时间点成像是可行的 从而潜在地增加了病变的显着性。最后，与一支高素质的团队合作 凭借肿瘤学、放射治疗、放射学和病理学的专业知识，我们将收集初步数据，以评估 与常规PET/CT相比，高质量探索者扫描在肿瘤成像中的附加值 扫描仪。

Abstract: The EXPLORER Consortium, through funding via a Transformative R01 and substantial commercial investment, has developed a 2-meter long total body PET scanner. This device has the potential to significantly alter the clinical application of PET through (a) substantial reduction in scan times, (b) substantial improvements in image quality, (c) substantial reduction in administered activity and (d) total-body coverage. This proposal aims to answer the basic questions that this new equipment raises with respect to the current clinical oncology application space: (1) how fast a scan can be performed to obtain standard diagnostic images using total-body PET; (2) whether breath-hold PET is feasible; (3) whether the scanner will support a 25-fold reduction in administered radiotracer activity; (4) whether there is value in delaying imaging to much later time-points after injection than current practice and (5) if the improvements in image quality obtained using standard injected doses and scan times have clinical utility. We will enroll 360 subjects from the clinical oncologic population seen at University of California, Davis; specifically, subjects affected by lung cancer, lymphoma and melanoma referred for PET/CT scan initial staging will be enrolled before starting treatment. We expect that the EXPLORER total-body PET scanner will be able to perform studies of similar diagnostic quality to conventional PET/CT scanners in approximately a minute or using a reduced dose corresponding to 1/25th of the standard dose. In addition we predict that breath-hold examinations will be feasible on EXPLORER. We also predict that very late time point imaging will be feasible on EXPLORER resulting in potential gains in lesion conspicuity. Finally, in collaboration with a team of highly-qualified team with expertise in oncology, radiation therapy, radiology and pathology, we will collect initial data to assess the added value of high-quality EXPLORER scans in oncologic imaging compared to conventional PET/CT scanners.