Methodologic Core

肌肉骨骼疾病很常见，会导致严重的残疾和医疗费用。 肌肉骨骼疾病的诊断和治疗的进展需要强有力的临床研究 基础设施和改善各种疾病的分类。后者对于精确度或 由于许多肌肉骨骼疾病都有共同的临床表现，个性化的医学方法 疼痛和身体功能受损，尽管有不同的病理生理学。此外，到目前为止，研究经常 重点放在骨骼或肌肉上，而不是它们如何相互作用。印第安纳州核心中心的总体主题是 临床研究(ICCCR)是为了加强肌肉骨骼疾病的临床研究，了解 通过更好地定义这一广泛的疾病类别或对其进行表型鉴定，以促进肌肉-骨骼连接 临床研究。ICCCR将利用包括印第安纳州和普渡大学在内的CTSA的校园资源 大学，我们全州的医疗保健系统，Regenstrief研究所的全州电子健康 记录系统，以及加强临床研究的精密健康倡议。ICCCR将与 由多学科研究人员组成的主题团队将创造创新的方式来思考肌肉骨骼 障碍表型。ICCCR将支持个人将调查人员和专题小组与 方法和资源核心，从而促进对1)利用的研究的访问和帮助 我们庞大的电子健康记录、组学和生物信息学网络，创建可计算的、基因的 和分子表型，2)开发标准化的身体功能和成像模式以开发 功能和形态表型，以及3)扩大印第安纳生物库的肌肉骨骼组织和 血液资源。ICCCR将与社区和行业合作伙伴合作，促进招聘和 技术转让和提供试点资金以支持新的研究。在方法论核心中，ICCCR 将培训、促进和支持调查人员扩大获得生物统计支持和项目的机会 通过利用大型数据库来定义和改进临床研究和患者健康 验证可计算的表型，并加速人类到替补席和反向循环 在肌肉骨骼的最新评估中协助研究人员发现肌肉骨骼 生物群落。ICCCR下的这些新的创新举措将把我们的肌肉骨骼联系在一起 印第安纳州肌肉骨骼研究中心的研究人员以最先进的资源鉴定小说 肌肉骨骼疾病的诊断和治疗目标。我们将挑战传统的方法 从长凳到床边的研究，而不是专注于患者的表型，从长凳到长凳，再回到研究。这将是 将多种肌肉骨骼疾病的定义和诊断提高到常见疾病 发病机制和临床表现，通过聚焦正确的治疗促进个性化药物治疗 每一位病人。

Musculoskeletal disorders are common and result in significant disability and health care costs. Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The latter is critical to precision or personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and technology transfer and provide pilot funding to support new research. In the Methodologic Core, the ICCCR will train, facilitate and support investigators to expand access to biostatical support and project review, enhance clinical research and patient health by leveraging large databases to define and validate computable phenotypes, and accelerate the human to bench and back cycle of musculoskeletal discovery by assisting investigators in state of the art evaluation of musculoskeletal biospecimens. These new and innovative initiatives under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized medicine by focusing the right treatment for each patient.