Environmental Liver Disease

肝病是一个主要的全球健康问题。脂肪肝，或脂肪在体内过度堆积 肝细胞，影响全球25%以上的成年人，但儿童和青少年也可能 受到影响。慢性肝病可能进展为肝硬变和肝癌，导致肝脏相关死亡或 移植。肝病也会影响糖尿病和心血管疾病的发展。肝 疾病可能由环境化学物质的暴露引起或影响，但这是一个研究较少的 区域。为了解决这些问题，本项目建立了一个重大的综合和协作研究 环境肝病革命性创新、富有远见的环境健康研究 计划(ELD-River)。 埃尔德-里弗将在这一领域产生革命性的影响。该项目调查了两个广泛的科学 主题：(1)内分泌和代谢干扰物(EDCs/MDCs)对脂肪肝的影响， 以及(Ii)与接触化学品有关的其他肝病(如肝癌)。ELD-River需要一段时间 通过研究相关化学物质的广泛的综合科学方法；营养：化学相互作用；两者 动物模型和人类受试者；以及通过包括多元组学在内的最先进方法的两性。 EDC/MDC暴露也可能通过其对肥胖和糖尿病的影响而影响肝脏疾病。因此，肥胖 糖尿病终点也将接受评估。 虽然具体的项目预计会随着时间的推移而发展，但最初的工作重点是暴露于 多氯联苯和氯乙烯。这两种化学品目前都在该机构的前五名之列 有毒物质和疾病登记处(ATSDR)物质优先列表。ELD-River严格遵守 科学严谨性和重复性原则以及数据透明度和可用性原则。ELD-River利用 多个组织之间的现有协作，包括学术界、政府机构、行业和 科学/医学学会。ELD-River的愿景是成为全球环境肝脏中心 疾病研究。为了完成翻译任务，该计划整合了基础科学家的工作， 流行病学家和医生。该项目还将开发诊断生物标记物、新的治疗方法、实践 指导方针，它有可能影响政策的变化。一路上，独特的机构教育/培训 将利用资源，使ELD-River将有助于产生下一代环境健康 科学家。建议的工作与国家环境卫生研究所的战略计划有关 科学(主题1、2和5以及目标1、4、7和8)。

Liver disease is a major global health problem. Fatty liver disease, or excess accumulation of lipids in hepatocytes, affects more than 25% of the worldwide adult population, but children and adolescents may also be affected. Chronic liver disease may progress to cirrhosis and liver cancer resulting in liver-related death or transplantation. Liver disease also impacts the development of diabetes and cardiovascular disease. Liver diseases may be caused or influenced by exposures to environmental chemicals, but this is an understudied area. To address these problems, this project establishes a major integrative and collaborative research program, the Environmental Liver Disease Revolutionizing Innovative, Visionary Environmental Health Research Program (ELD-RIVER). ELD-RIVER will have a transformative impact in the field. The project investigates two broad scientific themes: (i) the impact of endocrine and metabolism disrupting chemicals (EDCs/MDCs) in fatty liver disease, and (ii) other liver diseases (such as liver cancer) associated with chemical exposures. The ELD-RIVER takes a broad integrative scientific approach by investigating relevant chemicals; nutrient:chemical interactions; both animal models and human subjects; and both sexes through state-of-the-art methods including multi-‘omics. EDC/MDC exposures may also impact liver disease through their effects on obesity and diabetes. Thus, obesity and diabetes endpoints will also be evaluated. While the specific projects are expected to evolve over time, the initial work focusses on exposures to polychlorinated biphenyls and vinyl chloride. Both of these chemicals currently rank in the top five in the Agency for Toxic Substances and Disease Registry (ATSDR) Substance Priority List. ELD-RIVER strictly adheres to the principles of scientific rigor and reproducibility and data transparency and availability. ELD-RIVER leverages existing collaborations between multiple organizations including academia, government agencies, industry, and scientific/medical societies. The vision is for ELD-RIVER to become the global hub for environmental liver disease research. To accomplish its translational mission, the program integrates the work of basic scientists, epidemiologists, and physicians. The project will also develop diagnostic biomarkers, new treatments, practice guidelines, and it has the potential to impact policy change. Along the way, unique institutional education/training resources will be utilized so that ELD-RIVER will help produce the next generation of environmental health scientists. The work proposed is relevant to Strategic Plan of the National Institute of Environmental Health Sciences (Themes 1, 2, and 5 and Goals 1, 4, 7, and 8).