Wearable Nanoelectronic Vapor Sensors for Transdermal Alcohol Monitoring

项目摘要 在这个商业化准备试验(CRP)计划项目中，Arborense将开发可现场使用的可穿戴设备 酒精生物监测器，坚固耐用，连续佩戴舒适，同时保持功能和 在第二阶段展示了性能，并进行为期4周的现场合规性研究，以确定产品- 市场适应。在美国，过度饮酒是第四大可预防的死亡原因。酒精- 在过去20年里，相关死亡人数大幅增加，其他饮酒的流行也是如此。 相关危害，如酒精使用障碍和与酒精有关的肝病。阿博尔塞斯(氏)可穿戴酒精 生物监测仪将满足对连续、方便使用和谨慎的监测设备的未满足的需求 无不适或耻辱的饮酒。这将导致更好的认识和遵守尊重 在普通公众中饮酒。Arborense获得了美国国家科学基金会第一阶段SBIR赠款(IIP-1548317)， 我们展示了概念验证石墨烯酒精传感器及其在人体志愿者测试中的可行性。 这导致了NIAAA第二阶段SBIR拨款(R44AA026119)，使我们能够建造灯光、独立和手腕- 集成了自校准电子设备和蓝牙收发器以传输数据的穿戴传感器模块 无线连接到我们的定制Android应用程序。在第二阶段，我们与密歇根大学合作验证 这些传感器模块在大规模的人体受试者测试中(82名人类参与者；测试了150多个传感器 在对多个身体部位的300多项单独测试中)。我们已经证明，我们当前的模块可以 以法定等级为基准，持续可靠地检测最高BAC水平的饮酒事件 酒精测定仪，有非常低的假阳性和低假阴性。在此CRP计划中，我们将合作 与Sundberg-Ferar(一家总部位于密歇根州的工业设计公司)合作，并融合了健壮性、人体工程学 精致和美观，以开发一个坚固和高保真的系统，将用于数周 通过密歇根大学的佩戴学习。我们还将在设计期间与我们的战略合作伙伴接触 整合市场接受所需功能的过程。我们的生物表演的成功- 显示器在这些真实世界的功能和可用性方面的测试是迈向市场的一个关键里程碑 审批和投产开发，将继续提供投资动力。

Project Summary In this Commercialization Readiness Pilot (CRP) Program project, Arborsense will develop field-ready wearable alcohol bio-monitors that are robust and comfortable to wear continuously while maintaining the functionality and performance demonstrated in Phase II, and conduct a field compliance study for 4 weeks to establish product- market fit. Excessive alcohol consumption is the fourth leading preventable cause of death in the US. Alcohol- related deaths have accelerated significantly in the past two decades as has the prevalence of other alcohol- related harms such as alcohol use disorder and alcohol-related liver disease. Arborsense’s wearable alcohol bio-monitor will address the unmet need for a continuous, convenient-to-use, and discreet device for monitoring alcohol consumption without discomfort or stigma. This will lead to better awareness and compliance with respect to alcohol use amongst the general public. Arborsense received an NSF Phase I SBIR grant (IIP-1548317) with which we demonstrated proof-of-concept graphene alcohol sensors and their feasibility in human volunteer tests. This led to an NIAAA Phase II SBIR grant (R44AA026119) that allowed us to build light, standalone, and wrist- worn sensor modules integrated with self-calibration electronics and Bluetooth transceiver to transmit data wirelessly to our custom Android app. In Phase II, we collaborated with the University of Michigan to validate these sensor modules in large scale human subject tests (82 human participants; more than 150 sensors tested in over 300 individual tests on multiple body locations). We have shown that our current modules can continuously and reliably detect drink events with peak BAC level >0.03% when benchmarked with legal grade breathalyzer and have very low false positives and low false negatives. In this CRP program, we will collaborate with Sundberg-Ferar (a Michigan based industrial design firm) and incorporate robustness, ergonomic refinements, and aesthetics to develop a rugged and high-fidelity system that will be utilized for a multi-week wear study through the University of Michigan. We will also engage with our strategic partners during the design process to incorporate features necessary for market acceptance. The successful performance of our bio- monitors in these real-world tests in terms of functionality and usability is a key milestone towards market approval and production development and will continue to provide investment momentum.