NCI X-ray free electron laser (XFEL) initiative
NCI X-ray free electron laser (XFEL) initiative
批准号:
10262391
负责人:
Yun Xing m wang
金额:
$70.14万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
ArrestinsAtomic Force MicroscopyAwardBiologicalBreast Cancer PreventionCCRCOVID-19 pandemicCellsCharacteristicsClinicCryoelectron MicroscopyCrystallizationCrystallographyDataDevicesDrug TargetingEventFoundationsFutureG-Protein-Coupled ReceptorsGenesGranulovirusHumanImageImmunotherapyKineticsLasersLigand BindingLigandsLightLymphocyteManuscriptsMembrane ProteinsMethodsMinor GrooveMolecularMonitorMusOrganismPaperPeer ReviewPhase TransitionPhysiologic pulseProcessProteinsProtocols documentationPublicationsRNARNA ConformationReactionReportingResearch PersonnelResearch Project GrantsResolutionRhodopsinRoentgen RaysScienceSourceStructureSynchrotronsTemperatureThe SunTimeUniversitiesVirionVisualVisualizationWorkaqueouscrystallinitydesignflexibilitymalignant breast neoplasmmolecular imagingmovienanocrystalnovel strategiespreventprogrammed cell death protein 1serial imagingsingle moleculex-ray free-electron laser
中文摘要
我们主要专注于分析过去收集的XFEL数据,并取得了一些基本发现。最重要的结果之一是发现了晶体状态下配体结合引发晶格相变的机制。这种机制是分子膜可视化的基础。研究结果被写成了手稿。LCLS的XFEL束流因2019年的升级而关闭,预计将于2020年中期投入使用,但由于COVID-19大流行而无法使用。
英文摘要
We have been mostly focusing on the analysis of the XFEL data that was collected in the past and made several fundamental discoveries. one of the most important results is the discovery of the mechanism of lattice phase transition triggered by ligand binding in a crystalline state. This mechanism is fundamental to the visualization of molecular movies. The results are being written in a manuscript. The XFEL beam at LCLS was shut down for an upgrade for 2019 and was expected to be operational in the middle of 2020 but was not available due to the COVID-19 pandemic.
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会议论文
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:8552680
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项目类别:
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资助金额:$127.85万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:8763088
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项目类别:
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资助金额:$147.83万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:10702344
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项目类别:
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资助金额:$256.09万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:8348990
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项目类别:
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资助金额:$104.24万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:8938491
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项目类别:
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资助金额:$58.99万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
NCI X-ray free electron laser (XFEL) initiative
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批准号:10014757
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项目类别:
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资助金额:$84.7万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:9344191
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项目类别:
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资助金额:$48.27万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
NCI X-ray free electron laser (XFEL) initiative
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批准号:10702611
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项目类别:
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资助金额:$17.07万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:10703062
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项目类别:
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资助金额:$68.29万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:7592685
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项目类别:
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资助金额:$83.95万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:10926637
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项目类别:
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资助金额:$59.07万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:10926008
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项目类别:
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资助金额:$221.52万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:8157289
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项目类别:
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资助金额:$123.78万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Function and Activity
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批准号:7965286
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项目类别:
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资助金额:$131.57万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:10262766
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项目类别:
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资助金额:$75.99万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:10487252
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项目类别:
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资助金额:$64.86万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
NCI X-ray free electron laser (XFEL) initiative
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批准号:10486909
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项目类别:
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资助金额:$59.87万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
Search for the Structural Basis of Biomacromolecular Fun
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批准号:7291757
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:9556851
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项目类别:
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资助金额:$43.78万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
SAXS Core
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批准号:9154344
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项目类别:
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资助金额:$43.03万
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财政年份:--
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负责人:Yun Xing m wang
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依托单位:
海外基金