Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)

项目摘要 印度纵向老龄化研究对痴呆症的协调诊断评估(LASI-DAD) 是第一个也是唯一一个关于晚年认知和痴呆症的具有全国代表性和公开可用的数据集 在印度。我们的首要目标是发展一流的、对老年认知和痴呆症的纵向研究。 并向更大的研究界提供丰富、高质量的数据，以增进我们对 老年认知功能衰退和痴呆症的风险因素。此外，我们管理协调的认知 评估协议(HCAP)，一套通用的认知测试电池，由一个国际网络使用 研究人员，使低收入国家和高收入国家的新的和创新的比较研究成为可能。 在本申请中，我们的目标是准备和收集LASI-DAD的第二波。我们会继续跟进。 在第二波采访所有第一波受访者，并招募新的符合年龄条件的受访者。使用Wave 2数据，我们的目的是在人群水平上估计痴呆症的发病率并调查其预测因素。 我们的目标也是研究四年时间内的认知变化及其相关性，并估计 痴呆症的经济负担和照顾负担。LASI-DAD提供了一个前所未有的学习关键字的机会 痴呆症和晚年认知衰退的可改变和不可改变的危险因素。丰富、协调的数据 关于认知测试和告密者报告，以及静脉血液分析和老年临床评估， 能够对社会人口和生物变量的影响进行跨国比较(例如 心血管、代谢和炎症因素)对晚年认知和痴呆症的影响。 对于第二波， 我们将进一步创新：(1)扩大我们的静脉血液检测，将总和 血清中的磷酸化tau蛋白；(2)改进个人PM2.5暴露的测量方法 移动传感器，识别不同空气污染排放源的相对贡献；(3) 使用基于Android的测听测试改进听力测试方案；(4)评估眼睛健康， 包括使用视网膜眼底照相；以及(5)评估护理负担。总而言之，这些发现 将对痴呆症发病率和认知能力的风险因素产生新的见解 下降，使人们更好地了解印度和其他国家预防痴呆症的潜在目标 世界各国。与第一波一样，我们将及时准备公共使用数据和码本 通过展品、培训网络研讨会和用户帮助台，积极构建 来自多个科学学科的研究人员的用户基础。

Project Summary The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative and publicly available dataset on late-life cognition and dementia in India. Our overarching goals are to develop a first rate, longitudinal study of late-life cognition and dementia in India and to provide rich, high-quality data to the larger research community to advance our understanding of risk factors of late-life cognitive decline and dementia. Further, we administer the Harmonized Cognitive Assessment Protocol (HCAP), a common set of cognitive test batteries used by an international network of researchers, enabling new and innovative comparative studies across both low- and high-income countries. In this application, we aim to prepare for and collect Wave 2 of LASI-DAD. We will conduct follow up interviews at Wave 2 with all Wave 1 respondents and also recruit newly age-eligible respondents. Using Wave 2 data, we aim to estimate the dementia incidence rate at the population level and to investigate its predictors. We also aim to study cognitive changes and their correlates over the 4-year time period and to estimate the economic and caregiving burden of dementia. LASI-DAD provides an unprecedented opportunity to study key modifiable and non-modifiable risk factors for dementia and late-life cognitive decline. Rich, harmonized data on cognitive tests and informant reports, as well as venous blood assays and geriatric clinical assessments, enable cross-country comparisons of the influence of sociodemographic and biological variables (e.g. cardiovascular, metabolic, and inflammatory factors) on late-life cognition and dementia. For Wave 2, we will further innovate by: (1) expanding our venous blood assays to include total and phosphorylated tau protein in serum; (2) improving the measurement of personal exposure to PM2.5 using mobile sensors and identifying the relative contributions of different air pollution emission sources; (3) improving the hearing test protocol using an Android-based audiometry test; (4) assessing ocular health, including the use of retinal fundus photography; and (5) assessing caregiving burden. Altogether, the findings of the proposed investigation will yield new insights on the risk factors for dementia incidence and cognitive decline, allowing a better understanding of potential targets for dementia prevention in India and other countries around the world. As with Wave 1, we will prepare public use data and a codebook in a timely manner and promote data usage through exhibits, training webinars, and a user help desk, actively building a user base of researchers from across multiple scientific disciplines.