Animal Behavior and Physiology Core (AB&P)

摘要 动物行为和生理学(AB&P)核心的使命是实现深度动物模型 通过提供尖端的行为学技术，实现表型分析和早期中枢神经系统药物和基因治疗的发现 向IDD研究界提供生理分析和相关的科学专业知识。符合 因此，AB&P Core的设计目的是将尖端行为和体内生理协同作用 分析。作为一个专注于体内IDD模型的机构，AB&P Core将为IDDRC提供统一的服务 研究人员在分子/细胞和临床/翻译IDDRC组件之间的界面。 核心支持(1)适当严格的实验程序的标准化和验证 和重复性，(2)定量和深入的哺乳动物IDD模型表型，和(3) 开发翻译生物标记物，特别是为了通过以下方式检测靶结合 实验治疗学。行为终点与数量生理终点的整合 生物标记物提供了一种评估临床前概念验证和临床试验准备情况的方法 建议的碘缺乏病治疗。随着新技术的出现，核心迅速将它们引入其 工具组合，并将其提供给核心用户。除了提供实验平台外， 核心在体内实验设计、信号分析和整体研究方面提供深厚的专业知识 释义。

ABSTRACT The mission of the Animal Behavior and Physiology (AB&P) Core is to enable deep animal model phenotyping and early-phase CNS drug and gene therapy discovery by providing cutting-edge behavioral and physiological assays and related scientific expertise to the IDD research community. In line with the mission, the AB&P Core is therefore designed to synergize cutting-edge behavior and in vivo physiology analysis. As a facility focused on in vivo IDD models, the AB&P Core will provide unified services to IDDRC investigators at the interface between the molecular/cellular and clinical/translational IDDRC components. The Core enables (1) the standardization and validation of experimental procedures with appropriate rigor and reproducibility, (2) quantitative and in-depth mammalian IDD model phenotyping, and (3) the development of translational biomarkers, particularly for purposes of detecting target engagement by experimental therapeutics. The integration of behavioral endpoints with quantitative physiological biomarkers provides a means for assessing both preclinical proof of concept and clinical trial readiness of proposed IDD treatments. As new technologies become available, the Core rapidly introduces them into its tool portfolio and makes them available to Core users. In addition to providing the experimental platforms, the Core provides deep expertise in in vivo experimental design, signal analysis and overall study interpretation.