Biostatistics & Data Science Core

(CORE C- BDSC：生物统计学和数据科学核心） 项目摘要 描述：生物统计学和数据科学核心（BDSC）提供全面和专业的分析工具 IDDRC用户需要支持定量实验设计，生物统计学和信息技术 特别强调机器学习。核心小组在以下两个领域拥有实质性专门知识： 分核心（1）生物统计学，与生物统计学系的教师，流行病学和信息学在 宾夕法尼亚大学（PENN）支持基础科学，临床试验和 观察性研究和随后的数据分析（2）信息学和机器学习，与教师 来自费城儿童医院生物医学健康信息学系（CHOP），提供 支持“组学”数据与解释、分类和预测沿着的高级数据集成 建模第三个次级核心将支助职业发展和教育。核心成员承诺 导师和老师。玛丽普特博士，生物统计学教授和研究生院前副院长 流行病学与生物统计学小组和生物统计学研究生课程的课程主席，是整体 核心主任和生物统计分核心主任。王凯博士，生物医学副教授 CHOP和病理学（PENN）的健康信息学和生物医学研究所高级研究员 Informatics是Informatics & Machine Learning Sub-Core的副总监。肖锐博士，助理 生物统计学和儿科学教授，是职业发展与教育子项目的副主任， 核心 与IDDRC的相关性使命：BDSC支持我们IDDRC的总体主题，特别是（1）有影响力 研究与智力和发育残疾有关的疾病的原因和治疗方法， (2)新一代缺碘症研究人员的职业发展和教育。BDSC是从 以前的生物统计学和生物信息学核心;它与其他IDDRC的活动相互作用和/或补充 核心以及研究项目。生物统计学教师（Putt和Xiao博士）来自这个完善的 核心与同事，信息学和机器学习专家王凯博士联手， 新的生物统计学和数据科学核心。生物统计学系，通过与IDDRC的长期联系， 整合到IDD生物医学研究的多个领域，从基础科学到临床和转化 药王博士通过他在机器学习和其他信息学方法方面的专业知识， 与IDDRC成员建立了合作关系，并在大脑疾病方面拥有丰富的经验， 新一代大数据分析和培训的激动人心的角度。 资格：这些服务提供给儿童医院的IDDRC批准用户， 费城/宾夕法尼亚大学（CHOP/PENN）和整个IDDRC网络中心的用户。

(CORE C- BDSC: BIOSTATISTICS & DATA SCIENCE CORE) PROJECT SUMMARY Description: The Biostatistics & Data Science Core (BDSC) provides comprehensive and expert analytic tools for IDDRC users desiring support in quantitative experimental design, biostatistics, and informatics techniques with particular emphasis on machine learning. The Core has substantive expertise in areas represented by two sub-cores (1) Biostatistics, with faculty from the Department of Biostatistics, Epidemiology & Informatics at the University of Pennsylvania (PENN) supporting experimental design of basic science, clinical trials and observational studies and the analysis of the ensuing data (2) Informatics and machine learning, with faculty from the Department of Biomedical Health Informatics at Children’s Hospital of Philadelphia (CHOP), providing support for high-level data integration of ‘omics’ data along with interpretation, classification and predictive modelling. A third sub-core will support Career Development and Education. Core members are committed mentors and teachers. Dr. Mary Putt, Professor of Biostatistics and former Associate Vice-Chair of the Graduate Group in Epidemiology & Biostatistics and Program Chair of the Biostatistics graduate program, is the overall Core Director and Director of the Biostatistics Sub-Core. Dr. Kai Wang, Associate Professor of Biomedical Health Informatics at CHOP and Pathology (PENN) and, and Senior Fellow of the Institute for Biomedical Informatics, is Associate Director of the Informatics & Machine Learning Sub-Core. Dr. Rui Xiao, Associate Professor of Biostatistics, and Pediatrics, is Associate Director of the Career Development & Education Sub- Core Relevance to IDDRC Mission: The BDSC supports the overall themes of our IDDRC, specifically (1) impactful research into the cause and treatment of conditions related to intellectual and developmental disability (IDD) and (2) career development and education of a new generation of IDD researchers. The BDSC evolved out of the previous Biostatistics & Bioinformatics core; it interacts with and/or complements the activities of the other IDDRC Cores as well as the Research Project. The Biostatistics faculty (Drs. Putt and Xiao) from this well-established core have joined forces with colleague, Dr. Kai Wang, expert in Informatics and Machine Learning to form the new Biostatistics & Data Science core. The Biostatistics faculty, through long association with the IDDRC, are integrated into multiple domains of IDD biomedical research, from basic science to clinical and translational medicine. Dr. Wang, through his expertise in machine learning and other informatics approaches, his recently established collaborations with IDDRC members and extensive experience in brain disorders, adds a new and exciting angle to the new generation of big data analytics and training. Eligibility: These services are available both to approved users of the IDDRC at Children’s Hospital of Philadelphia/University of Pennsylvania (CHOP/PENN) and to users at Centers throughout the IDDRC Network.