1/2 Howard-Georgetown Collaborative Partnership In Cancer Research

总体摘要 NCI癌症研究合作P20伙伴关系的总体目标是提高癌症 在霍华德大学的研究能力，并增加参与癌症健康差异研究， 乔治城隆巴迪综合癌症中心（Georgetown Lombardi Comprehensive Cancer Center）伙伴关系的目标将通过 两个主要机制：试点研究项目和癌症研究教育。P20将受益于 内部咨询委员会（IAC）由高素质和经验丰富的科学家组成。的 研究试点项目将资助四个为期两年的合作研究试点项目。每个项目将包括在 霍华德和乔治城各一名调查员研究者将受益于HU/GU CTSA和GU提供的共享资源。试点项目1将确定候选基因和遗传 与非酒精性脂肪性肝病（NAFLD）相关的途径。这项研究将提供可能的信息 生物学机制潜在的分子和遗传签名的扰动代谢和机制 非裔美国人人群中NAFLD患者的通路。结果可能导致创新的非侵入性 生物标志物。研究项目2将调查慢性压力，生活质量和身体活动的差异 在黑人和白色乳腺癌幸存者中。这项研究将提供深入了解是否存在关联 乳腺癌幸存者的体力活动和非稳态负荷之间的关系。在颁奖过程中，P20 合作伙伴关系将通过竞争性进程，以择优方式开展另外两项试点研究 由IAC审核。试点项目的预期成果是成功提交合作赠款 通过试点研究获得的初步数据支持的应用。C-REP将为 伙伴关系的目标，通过参与多元化的学生和教师谁是代表不足， 生物医学研究的研究者。由大三或大四的大学生组成的群体 每年，研究生和专业学生将被招募为一个密集的8周辅导夏季 研究经验。后续辅导将提供，以促进进入研究生或专业 计划或博士后研究培训。博士后研究员和教师将接受培训和指导 支持获得一个强大的，高质量的出版记录和提交高度竞争性的独立 研究提案。C-REP内部的指导将通过来自双方的至少一名教师组成的团队进行 机构职能体系霍华德-乔治敦P20伙伴关系带来了许多优势，包括一个大型的游泳池， 代表霍华德大学的学生和教师，通过GU广泛的研究资源，以及 这是两个机构之间长期、富有成效的伙伴关系的基础。

Overall Abstract The overarching goal of the NCI Collaborative P20 Partnership in Cancer Research is to enhance cancer research capacity at Howard University and increase participation in cancer health disparities research at Georgetown Lombardi Comprehensive Cancer Center (GU). The Partnership goals will be achieved through two primary mechanisms: pilot research projects and cancer research education. The P20 will benefit from the guidance of an Internal Advisory Committee (IAC) made up of highly qualified and experienced scientists. The Research Pilot Projects will fund four 2-year collaborative research pilot projects. Each project will include at least one investigator from Howard and one from Georgetown. The investigators will benefit from the HU/GU CTSA and the Shared Resources available at GU. Pilot project 1 will identify candidate genes and genetic pathways associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The research will inform possible biological mechanisms underlying the molecular and genetic signatures of perturbed metabolic and mechanistic pathways in NAFLD patients in an African–American population. Results may lead to innovative non-invasive biomarkers. Research Project 2 will investigate disparities in chronic stress, quality of life, and physical activity among Black and White breast cancer survivors. This study will provide insight into whether an association exists between physical activity and allostatic load in breast cancer survivors. During the course of the award, the P20 Partnership will elicit two additional pilot studies through a competitive process which will be driven by a merit review by the IAC. The expected outcome of the pilot projects is the submission of successful collaborative grant applications supported by the preliminary data obtained via the pilot research. The C-REP will contribute to the goals of the Partnership by engaging a diverse group students and faculty who are under-represented as investigators in biomedical research. A cohort consisting of a mix of college students in their junior or senior year, graduate and professional students will be recruited annually for an intensive 8-week mentored summer research experience. Follow-up mentoring will be provided to promote entry into a graduate or professional program or postdoctoral research training. Postdoctoral fellows and faculty will receive training and mentoring to support attaining a robust, high quality publication record and submission of highly competitive independent research proposals. Mentoring within the C-REP will occur via teams of at least one faculty member from both institutions. The Howard-Georgetown P20 Partnership brings many strengths including a large pool of under- represented students and faculty at Howard University, extensive research resources through GU, and a foundation of longstanding, productive partnerships between the two institutions.