Optimizing mHealth for adherence monitoring and intervention

项目摘要 概况. K24职业生涯中期调查员奖的申请旨在支持初级 对移动健康感兴趣的研究人员，以改善对艾滋病毒和相关疾病的依从性监测和干预 合并症 候选人：Haberer博士是一名执业内科医生，马萨诸塞州总医院的研究主任 医院（MGH）全球健康中心，以及哈佛医学院医学副教授 （HMS）。她有近10年的研究抗逆转录病毒治疗依从性的经验， 在发展中环境中治疗和预防艾滋病毒，特别关注移动健康。哈伯雷博士是 被认为是她所在领域的领导者，特别是在电子依从性监测和基于SMS的 监测和干预。Haberer博士也是一位敬业的导师，并支持了21名博士预科生。 学生，居民，博士后研究员和初级教师，无论是在波士顿和国外。她的学员 写了18篇第一作者论文（另外5篇论文正在进行中），并与她一起获得了6项NIH资助的赠款 指导作为她指导的证明，她在2014年赢得了著名的HMS青年导师奖。 指导计划：Haberer博士的指导目标是：1）增加基于移动健康的指导活动 坚持监测和干预; 2）在MGH中心建立一个结构化的指导计划， 全球健康。她还可以通过MGH，HMS和其他哈佛附属机构访问学员 作为她在东非的研究合作机构。Haberer博士目前是两个R 01的主要研究者 通过NIMH的赠款，以及通过比尔和梅林达盖茨基金会的大规模赠款。她 因此，有能力让许多学员参加她正在进行的研究，通过分析 现有数据和补充项目。哈伯雷尔博士还将扩大她的研究， 科学，她将从事更多的学员。她收到了越来越多的 需要本奖项支持的指导请求。 研究计划：Haberer博士建议将她的研究计划扩展到实施科学， 基于移动健康的依从性监测和干预。这一目标包括获得以下方面的正式培训： 实施科学，以及对电子ART的使用进行实施科学研究 在乌干达进行依从性监测，并支持常规临床护理。她的目标是1）进行多层次的 形成性工作，以设计初步的实施战略; 2）使用迭代方法来优化 基于研究实施统一框架的实施策略。这 拟议的研究将有助于确定如何将有效的移动健康工具从研究背景转移到 常规临床护理，以及推进哈伯雷尔博士的职业生涯，并作为一个平台，学员参与。

Project summary Overview. This application for a K24 mid-career investigator award proposes to support mentoring for junior investigators interested in mHealth to improve adherence monitoring and intervention for HIV and related comorbid conditions. Candidate: Dr. Haberer is a practicing internist, the Director of Research at the Massachusetts General Hospital (MGH) Center for Global Health, and an Associate Professor of Medicine at Harvard Medical School (HMS). She has nearly 10 years of experience studying adherence to antiretroviral therapy for both the treatment and prevention of HIV in developing settings, with a particular focus on mHealth. Dr. Haberer is considered a leader in her field and most specifically in electronic adherence monitors and SMS-based monitoring and intervention. Dr. Haberer is also a dedicated mentor and has supported 21 pre-doctoral students, residents, post-doctoral fellows and junior faculty, both in Boston and abroad. Her mentees have written 18 first author papers (5 additional papers are in process) and received six NIH-funded grants with her guidance. As a testament to her mentoring, she won the prestigious HMS Young Mentor Award in 2014. Mentoring Plan: Dr. Haberer’s mentoring goals are to 1) increase mentoring activities in mHealth-based adherence monitoring and intervention; and 2) establish a structured mentoring program at the MGH Center for Global Health. She can access mentees through MGH, HMS, and other Harvard-affiliated institutions, as well as her research partner institutions in East Africa. Dr. Haberer is currently the principal investigator on two R01 grants through NIMH, as well as a large scale grant through the Bill and Melinda Gates Foundation. She therefore has the capacity for numerous mentees to participate in her on-going studies through analysis of existing data and supplemental projects. Dr. Haberer will also be expanding her research into implementation science, in which she will engage additional mentees. She has been receiving an increasing number of requests for mentorship that would require the support of this award. Research Plan: Dr. Haberer proposes to expand her research program into implementation science for mHealth-based adherence monitoring and intervention. This goal involves both acquiring formal training in implementation science, as well as conducting implementation science research on the use of electronic ART adherence monitoring plus support for routine clinical care in Uganda. She aims to 1) conduct multi-level formative work to design a preliminary implementation strategy; and 2) use an iterative approach to optimize the implementation strategy based on the Consolidated Framework for Research Implementation. This proposed research will help determine ways to move effective mHealth tools from the research context into routine clinical care, as well as advance Dr. Haberer’s career and serve as a platform for mentee involvement.