Pilot and Feasibility Program

项目摘要 UAB-UCSD O‘Brien中心试点和可行性(PAF)赠款计划的主要目标是 为与AKI相关的新的、突出的和创新的研究提案提供种子资金。这些飞行员 基金将为符合条件的调查人员提供一到两年的支持，以及必要的资源 探索由调查人员发起的与AKI相关的项目。 UAB-UCSD O‘Brien中心PAF计划将有三方重点关注，任务1)吸引 初级教员参与AKI相关研究；2)使其他领域的资深研究人员能够探索可行性 在与AKI相关的研究中引入新的创新概念；以及3)吸引具有研究专长的调查人员 核心中心的主题领域将其专业知识应用于与AKI相关的问题。PAF计划已经被 成功地完成了这项任务。有很高的经常性兴趣，平均每年有19份申请 对我们的RFA做出回应。所有的资助申请都被我们的研究组评为非常有价值的， 由我们的内部专家组成。该计划招募了12名内科科学家和11名博士科学家， 包括来自加州大学伯克利分校和加州大学圣地亚哥分校以外的机构的有前途的教师。23名调查人员中有18人获得了资金 这项计划是AKI领域的新成员，约83%的人仍在进行与肾脏相关的研究。这些 调查人员表现出了显著的工作效率，包括Pilot发表的39篇同行评议的论文 在此周期内获得资助的收件人。目前，23名获奖者合计成功率为66.7% 获得随后的外部资金。UAB-UCSD O‘Brien Center PAF计划将继续 利用UAB和UCSD的机构资源(本周期为335,000美元)，这将允许 增加我们的试点计划接受者的总投资。将继续每年颁发三至四个奖项 将由该计划支持，其中两个由奥布莱恩中心基金支持，另外1-2个由 机构基金。 UAB-UCSD O‘Brien Center PAF计划的最终目标是提供足够的资源和 对飞行员调查人员进行培训，以进行促进AKI治疗的研究。

Project Summary The principal objective of the UAB-UCSD O'Brien Center Pilot and Feasibility (PAF) Grants Program is to provide seed funds for new, outstanding, and innovative research proposals related to AKI. These pilot funds will provide eligible investigators with one to two years of support along with the resources necessary to explore investigator-initiated projects related to AKI. The UAB-UCSD O'Brien Center PAF Program will have a tri-partite focus with a mission 1) to attract junior faculty to AKI-related research; 2) enable established investigators in other fields to explore the feasibility of new, innovative concepts in AKI-related research; and 3) entice investigators with research expertise in the Core Center's thematic areas to apply their expertise to AKI-related questions. The PAF Program has been successful in this mission. There is a high level of recurring interest, with an average of 19 applications/year in response to our RFAs. All funded applications were judged to be highly meritorious by our study section, which consists of our intramural experts. The Program has recruited 12 physician-scientists and 11 Ph.D. scientists, including promising faculty from institutions outside UAB and UCSD. Eighteen of the 23 investigators funded by this program were new to the AKI field, and about 83% have remained in kidney-related research. These investigators have demonstrated significant productivity, including 39 peer-reviewed papers published by pilot recipients funded during this cycle. At present, collectively the 23 recipients have a 66.7% success rate in obtaining subsequent extramural funding. The UAB-UCSD O'Brien Center PAF Program will continue to leverage institutional resources ($335,000 during the present cycle) at both UAB and UCSD, which will permit an increase in the total investment for our Pilot Program recipients. Three to four awards per year will continue to be supported by this program, with two supported by O'Brien Center funds and the additional 1-2 from institutional funds. The ultimate goal of the UAB-UCSD O'Brien Center PAF program is to provide sufficient resources and training for pilot investigators to pursue research that advances the treatment of AKI.