Molecular Oncology Training Program

项目摘要 这是一项重新资助哥伦比亚大学最近设立的博士后培训项目的建议， 关于培训医生的研究技术，这将构成职业生涯的基础，在翻译调查， 癌症生物学、诊断和治疗。我们将确定和招募具有杰出研究的个人 有潜力的人已经完成了医学肿瘤学的临床培训，并为他们的生产性职业生涯做好准备， 肿瘤学的翻译研究者。我们将利用一个全面的两年计划，包括教学法， 研讨会，小组会议，课程，包括可能的硕士学位，和个性化的培训 在哥伦比亚大学教师的研究计划中，发展参与者的职业生涯。资金 每年最多可支助6名受训人员。 分子肿瘤学培训计划教师由46名独立研究人员组成，他们将提供 直接监督学员。教师由NCI统一资助，其他分支机构 NIH和其他以癌症为重点的研究组织，并已确立了自己作为思想领袖的地位， 广泛的癌症相关学科。教师分为主要专题领域的 培训计划：I）精确肿瘤学和系统生物学，II）癌症基因组学和表观基因组学，III） 肿瘤生物学和微环境。参与教师已确定的基础上，他们的研究 生产力和质量，表现出与其他研究人员的合作，往往是跨学科的研究， 以及支持和发展超越博士后水平的研究事业的历史。的 受训人员将从一组经过严格挑选的忠诚的医生研究人员中竞争性地挑选出来， 过去的成就和他们的潜力，发展职业生涯作为生产力，独立的翻译 investigators. 分子肿瘤学培训计划将得到哥伦比亚大学各种研究资源的支持 大学和正在进行的扩张和承诺，肿瘤学，包括实验室和 临床聚焦研究欧文癌症研究中心的成立预示着这种扩张 哥伦比亚大学欧文医学中心内一座30万平方英尺的建筑， 癌症研究和正在进行的招聘领先的临床转化研究教师的司 血液学和内科肿瘤学。这些变化大大拓宽了研究的多样性， 哥伦比亚大学与随之而来的质量提高，建立了哥伦比亚在顶级的 肿瘤学项目，并吸引了一批受过消费者培训的医生，他们致力于 转化癌症生物学

PROJECT SUMMARY This is a proposal to re-fund a recently established post-doctoral training program at Columbia University focused on training physicians in research techniques that will form the basis of careers in translational investigation of cancer biology, diagnosis and treatment. We will identify and recruit individuals with outstanding research potential who have completed clinical training in medical oncology and prepare them for productive careers as translational investigators in oncology. We will utilize a comprehensive two-year program comprised of didactics, workshops, small group sessions, coursework, including a possible master's degree, and individualized training within the research programs of Columbia University faculty to develop the careers of the participants. Funds are requested in a graded fashion to support up to 6 trainees annually. The Molecular Oncology Training Program faculty is comprised of 46 independent investigators who will provide direct supervision of the trainees. The faculty members are uniformly funded by the NCI, other branches of the NIH and other cancer-focused research organizations and have established themselves as thought-leaders in a broad range of cancer-related disciplines. Faculty members are divided into the main thematic areas of the training program: I) Precision Oncology and Systems Biology, II) Cancer Genomics and Epigenomics and III) Tumor Biology and Microenvironment. Participating faculty have been identified on the basis of their research productivity and quality, demonstrated collaboration with other investigators, often across research disciplines, and a history of supporting and developing research careers that transition beyond the post-doctoral level. The trainees will be chosen competitively from a highly select group of committed physician researchers on the basis of past accomplishments and their potential to develop careers as productive, independent translational investigators. The Molecular Oncology Training Program will be supported by the diverse research resources at Columbia University and the ongoing expansion and commitment to oncology that has included both laboratory and clinically focused research. The expansion was heralded by the opening of the Irving Cancer Research Center a 300,000 square-foot building within the Columbia University Irving Medical Center that is entirely dedicated to cancer research and the ongoing recruitment of leading clinical-translational research faculty to the Division of Hematology and Medical Oncology. These changes have significantly broadened the diversity of research at Columbia University with a concomitant increase in quality that has established Columbia in the top tier of oncology programs and has attracted a pool of consummately trained physicians committed to careers in translational cancer biology.