VIMORTP (Vanderbilt Integrated Molecular Oncology Research Training Program)

项目摘要 分子肿瘤学发现和临床实践整合的进展速度是无与伦比的。 现代癌症医学已经实现了从模式生物到以人为基础的系统研究的飞跃， 创建大量数据、快速集成和解释这些数据所必需的工具已经出现 同步此外，科学的飞跃也伴随着重要性的急剧增加。 转化研究和高质量的临床研究。结果是对熟练工人的需求增加， 工作人员谁能够翻译的调查结果作出了在板凳上，有一个广泛的了解工作 与人类样本和数据，谁是有能力的沟通者，谁有技能，能够使 与人类疾病的联系我们的目标是培养一批训练有素，积极主动， 在这个竞技场中，有效的临床研究人员和转化科学家，他们准备领导未来的 肿瘤学研究领域的进展。范德比尔特大学和范德比尔特大学医学中心 （“范德比尔特”）在个性化或精准医学方面有着悠久的研究历史， 分子肿瘤学研究的深度。此外，我们有一个长期和安全的MD-PhD管道， 杰出的医学博士学员加入我们的计划，由于哈里森社会医生科学家培训计划 在内科，儿科医生科学家管道，和霍尔曼学者计划在辐射 肿瘤学是范德比尔特教育平台的一个主要成功。我们建议 培训计划，建立在这一基础上，并选择1-2临床研究员水平的学员，每年为一个 强化指导的培训经验。我们提出以下目标：1）促进 发现和实施研究的基础知识，在他们选定的专业领域，2）提供 沟通技巧和团队建设方面的结构化指导，以满足未来管理方面的领导需求 研究团队，3）提供方案编写和手稿准备方面的重点培训，以及4）确定 并培养能代表我们人口多样性的受训人员。学员将获得 有机会在统计方法学、信息学战略、人体组织等方面扩大所需技能 研究或肿瘤免疫学。我们召集了一批强大的导师， 癌症研究、肿瘤免疫学、药物开发和癌症流行病学。我们一起准备 培养新一代的临床研究人员，他们准备加入并领导令人兴奋的 这些发展有望提高我们检测、管理和治愈癌症的能力。

PROJECT SUMMARY The pace of advances in molecular oncology discovery and integration to clinical practice is unparalleled. Modern cancer medicine has made the leap from model organism to studies in human-based systems, and the tools necessary to create large quantities of data, and to integrate and interpret them rapidly, have emerged simultaneously. In addition, the scientific leap has been accompanied by a dramatic increase in the importance of translational research and high quality clinical investigation. The result is an increased need for skilled workers who are able to be translate findings made at the bench, to have a broad understanding of working with human samples and data, who are capable communicators, and who have the skillset to be able to make informed connections to human disease. Our goal is to foster a cohort of highly trained, motivated, and effective clinician-investigators and translational scientists in this arena, who are poised to lead the coming advancements in the field of oncology research. Vanderbilt University and Vanderbilt University Medical Center (“Vanderbilt”) has a strong history of research in personalized or precision medicine, as well as significant depth in molecular oncology research. In addition, we have a longstanding and secure pipeline of MD-PhD and exceptional MD trainees joining our program, owing to the Harrison Society physician scientist training program in internal medicine, the pediatric physician-scientist pipeline, and the Holman Scholar Program in radiation oncology that have been a major successes of the Vanderbilt educational platform. We are proposing a training program that builds on that foundation, and selects 1-2 clinical fellow level trainees each year for an intensively mentored training experience. We propose the following aims: 1) to facilitate training in the fundamentals of discovery and implementation research in their selected area of expertise, 2) to provide structured mentoring in communication skills and team building for the future leadership needs in managing research teams, 3) to deliver focused training in protocol writing and manuscript preparation, and 4) to identify and develop trainees who are representative of the diversity of our population. Trainees will be provided an opportunity to expand skills where needed, in statistical methodology, informatics strategy, human tissue investigation, or tumor immunology. We have assembled a strong cohort of mentors representing translational cancer research, tumor immunology, drug development, and cancer epidemiology. Together, we are prepared to develop a new generation of clinician-investigators who are prepared to join and lead the exciting developments that promise to improve our ability to detect, manage, and cure cancer.