Cancer Epidemiology Research Program

摘要：癌症流行病学规划 癌症流行病学项目研究癌症和癌症的环境、遗传和分子风险 结果以确定公共卫生和临床干预的优先事项。该计划有三个目标：(1)风险- 以风险为基础的预防和早期发现：识别基于风险的预防和早期发现的机会 癌症；(2)治疗、结果和存活率：改善癌症治疗、结果和 通过流行病学和临床研究存活下来，导致循证干预；(3) 综合分子流行病学：加深对癌症病因、异质性和 通过对前驱病变和肿瘤进行综合的人类分子和组织病理学研究而存活。 一个主要的交叉主题是解决健康差距的流行病学问题。作为一种综合性癌症 作为一个经济、社会和种族多元化的州的中心，行政长官已经做好了解决健康公平问题的准备。 在这些目标中，我们使用北卡罗来纳州的多维研究并进行跨计划研究 产生高影响力的调查结果。成员在以人口为基础的流行病学、数据联系、 药物流行病学、调查研究、临床研究、筛查、分子和生物标志物研究， 翻译临床前研究、社会学、病理学、基因组学、数据科学、计算机科学和 统计学和流行病学方法。研究资源包括基于人群的乳房、结肠、 前列腺癌、头颈癌以及乳房和肺部筛查登记。这些研究中有许多 参与大型国家和国际数据共享倡议和联合体。该计划带来了价值 通过收集暴露和结果数据的研究资源，以及独特的 共享资源(全州癌症数据)和流行病学方法方面的专业知识。该计划受支持 由UNC Lineberger在教师招聘、共享资源和发展基金方面的投资。这个 北卡罗来纳州莱恩伯格大学的战略计划强调优化北卡罗来纳州的癌症结果 在人口科学方面的重大投资，并在未来几年扩大到新的领域，包括 子宫内膜和膀胱，持续支持乳腺癌和头颈部的持续数据收集 颈部癌症。CE计划由33名成员组成，他们与北卡罗来纳大学的9个部门有关联- 教堂山及其附属机构。在上一个资助期内，计划成员发表了776篇文章 与癌症相关的文章，24%是方案间的，19%是方案内的(34% 协作)。2019年，我们的计划成员在癌症相关领域获得了总计1000万美元(直接成本)的赠款 外部资金，包括NCI提供的520万美元(直接费用)和300万美元的其他同行审查资金。

ABSTRACT: CANCER EPIDEMIOLOGY PROGRAM The Cancer Epidemiology program studies environmental, genetic, and molecular risks for cancer and cancer outcomes to identify priorities for public health and clinical intervention. The program has three aims: (1) Risk- Based Prevention and Early Detection: To identify opportunities for risk-based prevention and early detection of cancer; (2) Treatment, Outcomes and Survivorship: To improve cancer treatment, outcomes, and survivorship through epidemiologic and clinical research that leads to evidence-based interventions; (3) Integrative Molecular Epidemiology: To deepen understanding of cancer etiology, heterogeneity, and survivorship through integrative human molecular and histopathologic studies of precursor lesions and tumors. A major cross-cutting theme is addressing the epidemiology of health disparities. As a comprehensive cancer center in an economically, socially, and racially diverse state, CE is well-poised to address health equity. Across these aims, we use multidimensional North Carolina studies and conduct cross-program research to yield high impact findings. Members have expertise in population-based epidemiology, data linkage, pharmacoepidemiology, survey research, clinical research, screening, molecular and biomarker research, translational preclinical research, sociology, pathology, genomics, data science, computer science, and statistical and epidemiologic methods. Research resources include population-based studies of breast, colon, prostate, head and neck cancer as well as registries for breast and lung screening. Many of these studies participate in large national and international data-sharing initiatives and consortia. The Program brings value to the Center through study resources that collect exposure and outcome data, and biospecimens, a unique shared resource (Statewide Cancer Data), and expertise in epidemiologic methods. The Program is supported by UNC Lineberger’s investments in faculty recruitments, shared resources and developmental funds. The UNC Lineberger strategic plan emphasis on optimizing cancer outcomes in North Carolina has led to significant investment across population sciences and is expanding in new areas in coming years including endometrium and bladder, with sustained support for ongoing data collection in breast cancer and head and neck cancers. The CE Program consists of 33 members who are associated with 9 departments at UNC- Chapel Hill and affiliated institutions. During the last funding period, program members have published 776 cancer-related articles, 24% were inter-programmatic and 19% were intra-programmatic (34% collaborative). In 2019, our program members held grants totaling $10.0M (direct cost) in cancer-relevant extramural funding, including $5.2M (direct costs) from the NCI and $3.0M other peer-reviewed funding.