Training in Translational Immunology Research

项目摘要 免疫学领域在过去的十年中爆炸式发展，主要是由于技术的发展， 对复杂的组织结构和系统的研究。转化免疫学研究是免疫学 以人类免疫疾病或疗法为导向的研究，最终旨在将基本的 实验室里的发现转化为改进的临床疗法。转化免疫学包括 分子和动物研究，解决人类疾病，同时强调对人类免疫的研究 系统中的迭代“工作台到床边和背部”的方法。因为免疫过程的控制 在癌症，传染病，移植和自身免疫研究的目标，在一个知识获得 该领域与应用免疫学的其他领域相关，因此需要在 学科为了利用我们在研究和控制能力方面取得的革命性飞跃， 人类免疫系统，需要多学科的培训，整合来自多个领域的知识 在基础和临床层面的学科，并教导年轻的科学家如何使用和分析获得的大数据 从高通量平台，如下一代测序，蛋白质组学，脂质组学和代谢组学。 分析这些数据集越来越需要尖端的生物信息学能力，这些能力必须被集成 培养下一代的翻译免疫学家我们提出了一个综合培训计划 为了满足这一需求，将哥伦比亚大学欧文医学中心的29名研究人员聚集在一起 （CUIMC），并在免疫学的六个互补领域提供指导研究机会：基础 免疫学、发育免疫学、病原体免疫、肿瘤免疫学、移植 . 免疫学和自身免疫。前沿研究沿着这些主题将得到支持的杰出 CUIMC系统生物学系我们相信这个全面的计划将使学员 整合生物信息学分析的前沿转化免疫学研究我们的最终目标是 该计划旨在为研究员提供必要的能力，使其成为未来翻译领域的领导者。 免疫学

Project Summary The field of immunology has exploded in the past decade, mainly as a result of technical developments enabling the study of complex organized structures and systems. Translational immunology research is immunological research that is oriented toward human immune diseases or therapies, ultimately aiming to convert basic discoveries made in laboratories into improved clinical therapies. Translational immunology encompasses molecular and animal research that addresses human diseases while emphasizing studies of the human immune system in an iterative “bench to bedside and back” approach. Because control of immunological processes is the goal of research in cancer, infectious disease, transplantation and autoimmunity, knowledge gained in one area is relevant to the other areas of applied immunology, resulting in a need for “horizontal translation” between disciplines. In order to harness the revolutionary leaps that have been made in our ability to study and control the human immune system, multidisciplinary training is needed that integrates knowledge from multiple disciplines at the basic and clinical levels and teaches young scientists how to use and analyze big data obtained from high throughput platforms such as next generation sequencing, proteomics, lipidomics and metabolomics. Analyzing these datasets increasingly demands cutting-edge bioinformatics capabilities that must be integrated into training the next generation of translational immunologists. We are proposing an integrative training program to meet this need by bringing together 29 established investigators at Columbia University Irving Medical Center (CUIMC) and offering mentored research opportunities in six complementary fields of immunology: basic immunology, developmental immunology, immunity to pathogens, tumor immunology, transplantation . immunology and autoimmunity. Cutting-edge research along these themes will be supported by the outstanding Department of Systems Biology at CUIMC. We believe this comprehensive program will expose trainees to cutting edge translational immunology research that integrates bioinformatics analyses The ultimate goal of our program is to provide fellows with the necessary competence to become future leaders in translational immunology.