Delaware Center for Musculoskeletal Research

项目总结/摘要 肌肉骨骼系统具有机械和生物功能-它产生，传输， 支持力量，并调节器官水平的稳态和全身代谢。力学和 肌肉骨骼系统的生物学是不可分割地交织在一起和长期的，其中机械线索， 分子信号和细胞相互作用在多个尺度上相互影响，从身体到器官，组织， 细胞和分子水平。肌肉骨骼研究的进展取决于解决力学和 邻近器官的生物学，以及评估损伤和衰老的影响。确定机制 潜在的肌肉骨骼健康和肌肉骨骼疾病（例如，骨关节炎，骨质疏松症，肌肉 浪费，创伤后修复，退化），因此需要一个研究范式，解决 肌肉骨骼系统内的协同作用，并结合机械和生物方法， 多尺度 特拉华州肌肉骨骼研究中心（DCMR）将支持基础和临床前 研究肌肉骨骼健康的中心主题-从整个身体的水平，以行动 的关键细胞和分子，重点是理解的机制， 生物线索影响组织结构和正常功能和功能障碍， 治疗干预。拟议的DCMR将： 目标1：通过支持协同和多学科研究，加速基础肌肉骨骼研究 研究项目。 目标2：通过建立多尺度评估，增强肌肉骨骼研究的能力 研究核心。 目标3：通过教师指导，扩展和保留来扩大肌肉骨骼研究的影响。 这个为期5年的第一阶段COBRE的完成将建立跨领域和协同研究合作 跨多规模和多学科的研究项目，并建立一个国家的最先进的研究核心。的 DCMR将专注于基础发现和临床前研究， 在特拉华州的翻译和临床肌肉骨骼研究计划，创造一个全面的基础， 临床研究管道通过促进跨领域和趋同的研究伙伴关系， DCMR旨在大幅减轻肌肉骨骼疾病的负担， 健康

PROJECT SUMMARY/ABSTRACT The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, cell, and molecule levels. Progress in musculoskeletal research depends on addressing the mechanics and biology of adjacent organs, and evaluating the effects of injury as well as aging. Identifying the mechanisms underlying musculoskeletal health and musculoskeletal disorders (e.g., osteoarthritis, osteoporosis, muscle wasting, post-traumatic repair, degeneration) therefore requires a research paradigm that addresses the synergies within the musculoskeletal system and combines both mechanical and biological approaches across multiple scales. The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health—from the level of the entire body to the actions of key cells and molecules—with emphasis on understanding the mechanisms by which physical and biological cues influence tissue structure and normal function and dysfunction, and identifying potential therapeutic interventions. The proposed DCMR will: Aim 1: Accelerate fundamental musculoskeletal research by supporting synergistic and multidisciplinary Research Projects. Aim 2: Galvanize capabilities for musculoskeletal research by establishing a Multiscale Assessments Research Core. Aim 3: Amplify the impact of musculoskeletal research through faculty mentoring, expansion, and retention. Completion of this 5-year Phase I COBRE will build cross-cutting and synergistic research collaborations across multi-scale and multidisciplinary Research Projects and establish a state-of-the-art Research Core. The DCMR, which will focus on fundamental discovery and preclinical research, will complement the outstanding translational and clinical musculoskeletal research programs at Delaware, creating a comprehensive basic-to- clinical research pipeline at UD. Through fostering cross-cutting and convergent research partnerships, the DCMR aims to substantially reduce the burden of musculoskeletal disorders and improve musculoskeletal health.