COBRE in Digestive and Liver Disease

基金家长奖摘要 消化与肝脏生物医学研究卓越中心(COBRE)的总体目标 疾病(CDLD)是为了在消化和疾病领域实现杰出的多学科协作研究 南卡罗来纳医科大学的肝病专家。这些疾病对人类健康很重要 南卡罗来纳州，因为他们承受着巨大的、不成比例的负担 该州的公民。具体目标是：1)指导不断扩大的成功青年干部队伍 研究人员将独立资助消化和肝病研究；2)开发 创新的科学核心资源，旨在刺激和应用研究发现 消化和肝脏疾病，以改善人类健康；以及3)维持CDLD及其长期 通过多学科研究和方案评估和改进取得成功 战略。该中心由一个由两个部门主任组成的多学科团队领导， MUSC医学院，整合资源以实现其总体目标 在南加州大学开发由NIDDK资助的Silvio O.Conte消化系统疾病研究核心中心。 科学核心包括：1)细胞模型核心，以生成消化系统的高级细胞模型 和肝病；2)以动物模型为核心的消化系统疾病提供必要的 动物模型；以及3)先进的成像核心，具有复杂的设备、技术和 成功、最先进的基于细胞和组织的成像和分析所需的专业知识。这 应用程序重点介绍四名初级调查人员，他们将受益于创新的多项 以内部和外部导师为特色的来源指导计划。与NIH和 机构支持，消化和肝病科布雷将促进 强大的翻译计划，最终导致更好的机械理解 有可能发现新的治疗方法。

Abstract of Funded Parent Award The overall goal of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enable outstanding multidisciplinary collaborative research in digestive and liver diseases at the Medical University of South Carolina. These diseases are of importance to the state of South Carolina because of the tremendous, disproportionate burden they have upon the state’s citizens. The specific aims are to: 1) Mentor an expanding cadre of successful Junior Investigators to become independently funded in digestive and liver disease research; 2) Develop innovative scientific core resources designed to stimulate and apply research discoveries in digestive and liver disease to improve human health; and 3) Sustain the CDLD and its long-term success through multidisciplinary research and programmatic evaluation and improvement strategies. The Center is led by a multidisciplinary team of two department chairs within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of developing an NIDDK-funded Silvio O. Conte Digestive Disease Research Core Center at MUSC. Scientific cores include the: 1) Cell Models Core to generate advanced cell models of digestive and liver diseases; 2) Animal Models of Digestive Diseases Core to provide access to essential animal models; and 3) Advanced Imaging Core with sophisticated equipment, technologies and expertise required for successful, state-of-the-art cell and tissue based imaging and analysis. This application highlights four Junior Investigators who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. With NIH and institutional support, the COBRE in Digestive & Liver Disease will facilitate the development of robust translational programs, ultimately leading to better mechanistic understanding with the potential for new therapeutic discoveries.