Acquisition of a MICRON IV ocular imaging system

摘要 致盲性眼病导致残疾显著增加，生活质量下降， 美国人研究这些条件和潜力背后的机制 治疗严重依赖于啮齿动物模型，因为它们与人眼相似， 易处理性然而，啮齿动物眼睛的小尺寸，以及伴随的光学差异， 这使得几乎不可能使用人类临床仪器来观察眼睛 啮齿动物的病理学这不仅限制了临床观察结果之间的直接相关性， 活的人类和啮齿动物中观察到的疾病过程，但 传统上也用于测定啮齿动物眼睛病理学的技术防止了大多数纵向 啮齿动物眼部病理学的研究凤凰-微米IV眼成像系统克服了 这些挑战是通过设计能够常规使用的方法的仪器的光学来实现的 在人类临床眼科护理中（眼底成像、荧光血管造影、光学相干 断层摄影术和裂隙灯），以匹配啮齿动物眼睛的成像，从而评估啮齿动物眼睛的 与人类相似的解剖结构。收购Micron IV 特拉华州大学的成像系统及其在我们的多模态动物中的放置 成像核心设施将扩大我们对致盲性眼病进行研究的能力， 还支持了为研究其他衰弱性疾病而建立的动物模型的眼部表型分析， 条件

Abstract Blinding eye diseases cause significant increases in disability and decreases in quality of life for Americans. Research into the mechanisms underlying these conditions and potential treatments relies heavily on rodent models due to their similarities to the human eye and genetic tractability. However, the small size of the rodent eye, and concomitant differences in optics with the human eye, makes it near impossible use human clinical instruments to view ocular pathology in rodents. This not only limits direct correlation between clinical observations in living humans and disease processes observed in rodents, but the invasive nature of the techniques also traditionally used to assay rodent eye pathology prevent most longitudinal studies of rodent eye pathology. The Phoenix-Micron IV ocular imaging system has overcome these challenges by engineering the optics of an instrument capable of methods used routinely in human clinical eye care (fundus imaging, fluorescence angiography, optical coherence tomography, and slit lamp) to match that of rodent eyes yielding assessments of rodent ocular anatomy that are comparable to those seen in humans. Thus, acquisition of the Micron IV imaging system by the University of Delaware and its placement in our multi-modal animal imaging core facility will expand our ability to perform research on blinding eye diseases while also supporting the ocular phenotyping of animal models created to study other debilitating conditions.