Delaware Clinical and Translational Research ACCEL Program

特拉华州临床和转化研究 ACCEL 计划

• 批准号: 10885455
• 负责人: Gregory E Hicks
• 金额: $ 20.91万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10885455
• 关键词: Acceleration; Adult; African American; Agreement; American; Area; Asian; Award; Biometry; Black race; Budgets; Caucasians; Cessation of life; Child Health; Childhood; Clinical; Clinical Research; Communities; Community Outreach; Delaware; Development; Epidemiology; Equity; Ethnic Origin; Evaluation; Funding; Goals; Grant; Growth; Health; Health Promotion; Healthcare; Healthcare Systems; Hispanic; Hospitals; Infrastructure; Institution; Intention; Investments; Learning; Letters; Malignant Neoplasms; Mission; Modeling; Modification; Native Americans; Obesity; Outreach Research; Pharmaceutical Preparations; Pilot Projects; Population; Population Heterogeneity; Population Research; Recommendation; Research Design; Research Personnel; Rural; Scientist; Societies; Structure; System; Time; Training; Translational Research; Universities; Work; Writing; clinical infrastructure; community engagement; design; health care quality; health equity; health inequalities; hospitalization rates; improved; innovation; member; multiple chronic conditions; population health; programs; racial diversity; recruit; translational research program; translational scientist

ABSTRACT- OVERALL This proposal is a competitive renewal of the Institutional Development Award Program Infrastructure for Clinical and Translational Research (IDeA-CTR)(U54) grant originally awarded in September 2013 to the University of Delaware. The ACCEL CTR Program, has completed nine years of funding at the time of this application. During our third funding cycle (ACCEL3), our consortium will consist of four partners: University of Delaware (UD)—the lead institution; Nemours Children’s Health (Nemours); Christiana Care Health System (CCHS), the largest health care system in Delaware; and Delaware State University (DSU), an American historically Black, public university that joined our consortium during the last competitive renewal. Over the past nine years, ACCEL has established an exceedingly strong network and infrastructure for clinical and translational (C&T) research within the state of Delaware; and, we are now poised and ready to continue our growth trajectory. While we will continue with the activities that have made us successful, we will have a sharper focus on building sustainable infrastructure across the state that can continue to thrive and mature for years to come. And, we will focus on creating a scientific culture focused, not only, on improving the health of Delawareans, but doing so through a lens of health equity. In our mission to establish a cadre of successful C&T scientists in DE, we will use various approaches to promote full consideration of how their work impacts the needs of all members of society, from design to study implementation to dissemination of findings. And, we will have a much greater focus on building a bi-directional relationship between our scientists and the community so that we can have a greater impact on Delawareans. Delaware is an ideal state for a CTR grant as it represents the whole of the USA in a compact form. The population of Delaware (~970,000) mirrors the US population in urban-to-rural citizen ratio and ethnic/racial diversity, with 23% African American, 62% Caucasian, 10% Hispanic, 4% Asian and 1% Native American. Thus, studies involving a cross-section of Delaware can be generalizable to populations nationally. The dominance of adult (CCHS) and pediatric (Nemours) hospital systems, which serve at least 85% of the residents of the state, provides a unique opportunity to treat the state of Delaware as a model for examining how healthcare changes can impact population health. The overarching goal of the ACCEL CTR Program is to create a unified Delaware Clinical and Translational Research Community (inclusive of investigators and community members) that breaks down existing barriers, capitalizes on the unique strengths of its partners to establish infrastructure and accelerates the creation of equitable solutions that improve the health of all Delawareans and all Americans.

摘要-总体 该提案是对机构发展奖计划基础设施的竞争性更新 临床和转化研究 (IDeA-CTR)(U54) 拨款最初于 2013 年 9 月授予 特拉华大学。 ACCEL CTR 计划截至 2017 年已完成九年的资助 这个应用程序。在我们的第三个融资周期 (ACCEL3) 中，我们的财团将由四个合作伙伴组成： 特拉华大学 (UD)——牵头机构；内穆尔儿童健康中心（内穆尔）；克里斯蒂安娜 护理医疗系统 (CCHS)，特拉华州最大的医疗保健系统；和特拉华州立大学 （DSU），一所美国历史悠久的黑人公立大学，去年加入我们的联盟 竞争性更新。在过去的九年里，ACCEL 建立了极其强大的网络 特拉华州临床和转化 (C&T) 研究基础设施；并且，我们是 现在已经准备好继续我们的增长轨迹。虽然我们将继续开展以下活动 使我们取得了成功，我们将更加专注于在各地建设可持续的基础设施 可以在未来几年继续繁荣和成熟的国家。并且，我们将专注于创建一个 科学文化不仅关注改善特拉华州人的健康，而且还通过镜头来实现这一目标 健康公平。为了在 DE 建立一支成功的 C&T 科学家骨干队伍，我们将使用 采取各种方法来促进充分考虑其工作如何影响所有成员的需求 社会，从设计到研究实施再到研究结果的传播。并且，我们将会有很多 更加注重在我们的科学家和社区之间建立双向关系，以便 我们可以对特拉华州人产生更大的影响。特拉华州是获得 CTR 补助金的理想州，因为它 以紧凑的形式代表整个美国。特拉华州的人口（约 970,000）反映了 美国人口的城乡公民比例和民族/种族多样性，其中 23% 为非裔美国人，62% 白种人、10% 西班牙裔、4% 亚洲人和 1% 美洲原住民。因此，涉及横截面的研究 特拉华州可以推广到全国人口。成人 (CCHS) 和儿童的主导地位 (内穆尔) 医院系统为该州至少 85% 的居民提供服务，提供了独特的服务 有机会将特拉华州作为研究医疗保健变化如何影响的模型 人口健康。 ACCEL CTR 计划的总体目标是创建一个统一的特拉华州 临床和转化研究社区（包括研究者和社区成员） 打破现有壁垒，利用合作伙伴的独特优势，建立 基础设施并加速创建公平的解决方案，以改善所有人的健康 特拉华州人和所有美国人。

项目成果

Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and Pediatric Cancer Therapy.

用于成人和儿童癌症治疗的细胞周期抑制剂化疗的开发。

• DOI: 10.1158/0008-5472.can-17-2782
• 发表时间: 2018-01-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Mills CC;Kolb EA;Sampson VB
• 通讯作者: Sampson VB

Cost Effectiveness of Antiplatelet and Antithrombotic Therapy in the Setting of Acute Coronary Syndrome: Current Perspective and Literature Review.

• DOI: 10.1007/s40256-015-0131-6
• 发表时间: 2015-12
• 期刊: American journal of cardiovascular drugs : drugs, devices, and other interventions
• 作者: Fanari Z;Weiss S;Weintraub WS
• 通讯作者: Weintraub WS

Congenitally Corrected Transposition of the Great Arteries: Fetal Diagnosis, Associations, and Postnatal Outcome: A Fetal Heart Society Research Collaborative Study.

• DOI: 10.1161/jaha.122.029706
• 发表时间: 2023-06-06
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Cohen J;Arya B;Caplan R;Donofrio MT;Ferdman D;Harrington JK;Ho DY;Hogan W;Hornberger LK;Jhaveri S;Killen SAS;Lindblade CL;Michelfelder E;Moon-Grady AJ;Patel S;Quezada E;Ronai C;Sanchez Mejia AA;Schidlow DN;Stiver C;Thakur V;Srivastava S
• 通讯作者: Srivastava S

Osteoprotegerin is a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes.

• DOI: 10.4158/ep14229.or
• 发表时间: 2015-01
• 期刊: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
• 作者: Maser RE;Lenhard MJ;Sneider MB;Pohlig RT
• 通讯作者: Pohlig RT

Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.

• DOI: 10.1111/pedi.12241
• 发表时间: 2015-03
• 期刊: Pediatric diabetes
• 影响因子: 3.4
• 作者: McCulloch MA;Mauras N;Canas JA;Hossain J;Sikes KM;Damaso LC;Redheuil A;Ross JL;Gidding SS
• 通讯作者: Gidding SS