Delaware Clinical and Translational Research ACCEL Program

特拉华州临床和转化研究 ACCEL 计划

• 批准号: 10885455
• 负责人: Gregory E Hicks
• 金额: $ 20.91万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10885455
• 关键词: Acceleration; Adult; African American; Agreement; American; Area; Asian; Award; Biometry; Black race; Budgets; Caucasians; Cessation of life; Child Health; Childhood; Clinical; Clinical Research; Communities; Community Outreach; Delaware; Development; Epidemiology; Equity; Ethnic Origin; Evaluation; Funding; Goals; Grant; Growth; Health; Health Promotion; Healthcare; Healthcare Systems; Hispanic; Hospitals; Infrastructure; Institution; Intention; Investments; Learning; Letters; Malignant Neoplasms; Mission; Modeling; Modification; Native Americans; Obesity; Outreach Research; Pharmaceutical Preparations; Pilot Projects; Population; Population Heterogeneity; Population Research; Recommendation; Research Design; Research Personnel; Rural; Scientist; Societies; Structure; System; Time; Training; Translational Research; Universities; Work; Writing; clinical infrastructure; community engagement; design; health care quality; health equity; health inequalities; hospitalization rates; improved; innovation; member; multiple chronic conditions; population health; programs; racial diversity; recruit; translational research program; translational scientist

ABSTRACT- OVERALL This proposal is a competitive renewal of the Institutional Development Award Program Infrastructure for Clinical and Translational Research (IDeA-CTR)(U54) grant originally awarded in September 2013 to the University of Delaware. The ACCEL CTR Program, has completed nine years of funding at the time of this application. During our third funding cycle (ACCEL3), our consortium will consist of four partners: University of Delaware (UD)—the lead institution; Nemours Children’s Health (Nemours); Christiana Care Health System (CCHS), the largest health care system in Delaware; and Delaware State University (DSU), an American historically Black, public university that joined our consortium during the last competitive renewal. Over the past nine years, ACCEL has established an exceedingly strong network and infrastructure for clinical and translational (C&T) research within the state of Delaware; and, we are now poised and ready to continue our growth trajectory. While we will continue with the activities that have made us successful, we will have a sharper focus on building sustainable infrastructure across the state that can continue to thrive and mature for years to come. And, we will focus on creating a scientific culture focused, not only, on improving the health of Delawareans, but doing so through a lens of health equity. In our mission to establish a cadre of successful C&T scientists in DE, we will use various approaches to promote full consideration of how their work impacts the needs of all members of society, from design to study implementation to dissemination of findings. And, we will have a much greater focus on building a bi-directional relationship between our scientists and the community so that we can have a greater impact on Delawareans. Delaware is an ideal state for a CTR grant as it represents the whole of the USA in a compact form. The population of Delaware (~970,000) mirrors the US population in urban-to-rural citizen ratio and ethnic/racial diversity, with 23% African American, 62% Caucasian, 10% Hispanic, 4% Asian and 1% Native American. Thus, studies involving a cross-section of Delaware can be generalizable to populations nationally. The dominance of adult (CCHS) and pediatric (Nemours) hospital systems, which serve at least 85% of the residents of the state, provides a unique opportunity to treat the state of Delaware as a model for examining how healthcare changes can impact population health. The overarching goal of the ACCEL CTR Program is to create a unified Delaware Clinical and Translational Research Community (inclusive of investigators and community members) that breaks down existing barriers, capitalizes on the unique strengths of its partners to establish infrastructure and accelerates the creation of equitable solutions that improve the health of all Delawareans and all Americans.

抽象——整体

项目成果

Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and Pediatric Cancer Therapy.

用于成人和儿童癌症治疗的细胞周期抑制剂化疗的开发。

• DOI: 10.1158/0008-5472.can-17-2782
• 发表时间: 2018-01-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Mills CC;Kolb EA;Sampson VB
• 通讯作者: Sampson VB

Cost Effectiveness of Antiplatelet and Antithrombotic Therapy in the Setting of Acute Coronary Syndrome: Current Perspective and Literature Review.

• DOI: 10.1007/s40256-015-0131-6
• 发表时间: 2015-12
• 期刊: American journal of cardiovascular drugs : drugs, devices, and other interventions
• 作者: Fanari Z;Weiss S;Weintraub WS
• 通讯作者: Weintraub WS

Congenitally Corrected Transposition of the Great Arteries: Fetal Diagnosis, Associations, and Postnatal Outcome: A Fetal Heart Society Research Collaborative Study.

• DOI: 10.1161/jaha.122.029706
• 发表时间: 2023-06-06
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Cohen J;Arya B;Caplan R;Donofrio MT;Ferdman D;Harrington JK;Ho DY;Hogan W;Hornberger LK;Jhaveri S;Killen SAS;Lindblade CL;Michelfelder E;Moon-Grady AJ;Patel S;Quezada E;Ronai C;Sanchez Mejia AA;Schidlow DN;Stiver C;Thakur V;Srivastava S
• 通讯作者: Srivastava S

Osteoprotegerin is a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes.

• DOI: 10.4158/ep14229.or
• 发表时间: 2015-01
• 期刊: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
• 作者: Maser RE;Lenhard MJ;Sneider MB;Pohlig RT
• 通讯作者: Pohlig RT

Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.

• DOI: 10.1111/pedi.12241
• 发表时间: 2015-03
• 期刊: Pediatric diabetes
• 影响因子: 3.4
• 作者: McCulloch MA;Mauras N;Canas JA;Hossain J;Sikes KM;Damaso LC;Redheuil A;Ross JL;Gidding SS
• 通讯作者: Gidding SS