E3Gen: Multigenerational Influences of Social Structure on Toxicant Exposures and Life Course Health in the ELEMENT Cohort

E3Gen：社会结构对毒物暴露和生命过程健康的多代影响 元素队列 摘要 传统的流行病学研究和方法往往分别关注社会、经济和环境 影响个人一生健康的因素，然而不断发展的研究强调了考虑 聚集在社会上处境最不利的人身上的各种因素的综合影响。多条机械路径 还必须考虑到复杂的联系，以了解社会结构和化学物质的影响 造成环境健康差距的暴露。这一挑战不仅取决于措施的整合 将社会经济地位纳入环境队列研究，但也包括关于 社区基础设施和社会条件，可以照亮个人的生活体验，并促进新的 科学方向。虽然大量研究检查了发育起源和潜在的生物机制 毒物-健康协会，很少有队列有能力解决毒物暴露的代际遗产 和关于生命过程健康的社会结构1这项U24竞争性续订应用程序利用了丰富的数据和研究 墨西哥早期生命暴露于环境毒物(元素)队列的基础设施。在这里，我们建议 扩大我们的E3Gen队列维护活动，以整合社会结构和人种学数据的新衡量标准 进入我们的生物和数据仓库，在这个独特的、多代人的母子二人组中，跟随了~28年 好几年了。这一扩展还将实施简化的协议，以加强后续行动并与原始要素接洽 随着后代过渡到成年并开始有自己的孩子，为研究检查奠定了基础 3.社会和环境暴露对生殖和代谢健康及发育的影响 几代人。具体目标是：1)创建和收集家庭和个人的定性和定量数据，以 了解社会和经济压力的直接影响及其改变多代人生活的潜力 环境暴露对健康结果的过程影响。2)鼓励参与，防止损失，跟进 在目前年龄在16-28岁的约600名元素子女中，建立被动监测来招募他们的孩子 并预计在未来5年内出生。3)开发和测试新的、非线性的多维方法 整合和协调定性和定量数据，促进跨项目数据沟通和创新 建立跨学科伙伴关系，并加快与更大的环境健康科学界共享数据。 通过我们与为少数族裔服务的机构汉普顿大学、菲斯克大学和斯佩尔曼学院现有的合作伙伴关系， 我们将通过暑期培训不同的学生，学习环境流行病学、全球公共卫生和生物统计学。 本科生实习和加速的硕士学位课程。 1戈克费尔德、迈克尔和乔安娜·汉堡。“环境正义和其他人群中不成比例的风险暴露：离群值的重要性。”《美国日报》 公共卫生部101.S1(2011)：S53-S63。

E3Gen: Multigenerational influences of social structure on toxicant exposures and life course health in the ELEMENT cohort SUMMARY Traditional epidemiological research and methods often focus separately on how social, economic, and environmental factors affect individuals’ life course health, yet evolving research underscores the importance of considering the integrated effects of factors that cluster in those who are most socially disadvantaged. Multiple mechanistic pathways with complex linkages must also be taken into account to understand the effects of social structures and chemical exposures that underlie environmental health disparities. This challenge depends not only on the integration of measures of socioeconomic status into environmental cohort studies, but also qualitative and geographic information on neighborhood infrastructure and social conditions that can illuminate individuals’ lived experiences and facilitate new scientific directions. While substantial research examines the developmental origins and biologic mechanisms underlying toxicant-health associations, few cohorts have the ability to address the intergenerational legacy of toxicant exposures and social structures on life course health.1 This U24 competitive renewal application leverages the rich data and research infrastructure of the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) cohort. Here, we propose expanding our E3Gen cohort maintenance activities to integrate novel measures of social structure and ethnographic data into our biologic and data repositories in this unique, multi-generational cohort of mother-child dyads followed for ~28 years. This expansion also will implement streamlined protocols to enhance follow-up and engage the original ELEMENT offspring as they transition to adulthood and begin to have children of their own, setting the stage for research examining the impact of social and environmental exposures on reproductive and metabolic health and development across 3 generations. Specific aims are to: 1) Create and collect household and individual qualitative and quantitative data to understand the direct effects of social and economic stressors and their potential to modify the multigenerational, life course effects of environmental exposures on health outcomes. 2) Encourage participation and prevent loss to follow up among ~600 ELEMENT offspring now aged 16-28 years and establish passive surveillance to recruit their children currently and projected to be born over the next 5 years. 3) Develop and test novel, nonlinear multidimensional methods to integrate and harmonize qualitative and quantitative data, foster cross-project data communication and novel interdisciplinary partnerships, and accelerate data sharing with the larger environmental health sciences community. Through our existing partnerships with minority-serving institutions Hampton and Fisk Universities and Spelman College, we will train diverse students in environmental epidemiology, global public health and biostatistics via summer undergraduate internships and accelerated master’s degree programs. 1 Gochfeld, Michael, and Joanna Burger. "Disproportionate exposures in environmental justice and other populations: the importance of outliers." American Journal of Public Health 101.S1 (2011): S53-S63.