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Novel Candidate Genes, Lung Function and Allergic Airways Disease

Novel Candidate Genes, Lung Function and Allergic Airways Disease
新候选基因、肺功能和过敏性气道疾病
批准号:
nhmrc : 546428
负责人:
A/Pr Chrishan Samuel
金额:
$38.8万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31

项目摘要

项目成果

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中文摘要
翻译
我们建议使用人类样本和啮齿动物哮喘模型来研究气道重塑(气道结构变化)和哮喘。我们对研究三叶肽2和松弛素的作用特别感兴趣,这两个基因被确定为决定肺功能。要做到这一点,我们需要了解气道重塑的机制及其对患者疾病严重程度的影响。这项研究的一个优势是可以从一项大型人类哮喘研究中获得样本。
英文摘要
We propose to study airway remodelling (structural changes to the airway) and in asthma using human samples and rodent models of asthma. We are particularly interested in investigating the role of trefoil peptide 2 and relaxin, two genes identified as determining lung function. To do this we need to understand the mechanisms of airway remodelling and its impact on disease severity in the patient. A strength of this study is availability of samples from a large study of human asthma.
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海外基金